PREVALENCE AND INCIDENCE
Systematic review of the literature finds that the most common disorders are dementia, delirium and depression, which together will account for about 80% of the psychiatric morbidity (Table 129.3). All three are substantially more common in general hospitals than found in the community, and all conditions combined are 3–4-times more common. Rates vary with hospital departments, being particularly high in medical and orthopaedics. There is very little known about rates in emergency departments.
Each of the three major disorders creates different problems and a different focus of approach, discussed later.
Despite mental disorder being so common, detection by general care teams is poor. The diagnosis of delirium is missed in 32–67% of cases15, and cognitive impairment in over half16. A meta-analysis of older medical admissions reported a median detection rate for depression of 10%17. In England, a national report found that only 41% of people with dementia had any form of mental assessment recorded18.
General care teams have difficulty understanding the concept of syndromes, and their response to mental disturbance is, predominantly, a reaction to symptoms. Consequently, crying, not eating, and thoughts of death are synonymous with depression, and any cognitive errors with dementia. Jackson and Baldwin19 reported how nurses on medical wards recognize symptoms of depression rather than the syndrome. A small qualitative study in the USA found that 75% of general nurses could not distinguish dementia from delirium, despite 75% saying that they had received formal education on the subject or had attended a conference about confusion in the elderly20.
Table 129.1 Characteristics of liaison and consultation services
Consultation | Liaison |
Reactive | Proactive |
Limited resources | More labour intensive |
Isolated input | Collaborative |
Low priority | High priority |
Little impact | Developmental Education and training |
Slow response | Rapid response |
Little review | Frequent review Improve quality of referrals Improve adherence of recommendations Change practice and attitudes |
Mental health separate from general services | Mental health integrated with general services |
Mental health physically distant from acute care | Mental health physically part of acute care |
Table 129.2 Benefits of liaison compared to consultation
Quicker response |
Increase referrals and quality of referral |
Increased specialist assessments |
Improved diagnostic concordance between referrer and assessment |
Better adherence with treatment recommendations |
Reduced length of admission |
More return to independent living |
Reduced readmission |
Reduced health care utilization |
Reduced cost |
High patient satisfaction |
Table 129.3 Average period prevalence of psychiatric morbidity (%)
Dementia | 31 |
Depression | 29 |
Delirium | 20 (50% incident) |
Cognitive impairment | 22 |
Anxiety | 8 |
Schizophrenia | 0.4 |
Alcoholism | 3 |
A further example, and one which emphasizes the importance of syndrome diagnosis, is a report on older people referred to a liaison service with depression when 40% were found to be suffering from delirium21. Depressive symptoms were as common in the delirious patients as those diagnosed with depression, 50% expressing a wish to die, 25% suicidal thoughts and the majority thoughts of worth-lessness and guilt.
But, detection in an acute hospital with serious physical co-morbidity can be difficult. Particularly so for depression, when key biological symptoms like fatigue, loss of appetite, weight and sleep can arise from physical or psychological illness, and evaluating loss of motivation and worry in people seriously physically ill is difficult.
A diagnostic approach to depression based on DSM-III-R22 criteria, counting all symptoms regardless of their origin (inclusive) or excluding any symptom that could arise from physical illness (exclusive), produces a variation in prevalence of 27 to 46%23. The exclusive approach had high specificity for severe and persistent major depression, but missed 49% of major depressions identified by the high-sensitivity inclusive approach, almost 60% of whom continued to experience symptoms of depression weeks after discharge. Furthermore, these findings are based on structured psychiatric interviews, and unstructured clinical impressions are less reliable.
Interpreting cognitive function can be similarly difficult. Is a person’s cognitive performance poor simply because they feel ill or too tired to attend? What is the significance of disorientation to day and date when a person has spent weeks or months in hospital or has been very ill?
It is partly for these reasons that mental health liaison teams are needed to develop expertise working in this environment. Assessment and diagnostic instruments do not solve this problem as they also need to be interpreted and few are validated for use with physically ill people. In untrained hands these tools can be dangerous, lead to false conclusions and the mistaken belief that a quick tick-box approach can replace the history and mental state examination.
Routine screening for cognitive impairment and depression has been suggested, but the benefit and method remain uncertain. A screening instrument would need high sensitivity (like the inclusive approach for depression described above) but would yield false positives, while a diagnostic instrument would require high specificity (like the exclusive approach for depression above), but risks missing many people with the disorder who would benefit from treatment.
A systematic review of screening for depression and anxiety in non-psychiatric settings concluded that the routine administration of psychiatric questionnaires with feedback to clinicians does not improve the detection of emotional disorders or patient outcome; although, those with high scores may benefit24. Studies of the systematic detection and multidisciplinary treatment of delirium or depression in medical inpatients have, so far, been unable to demonstrate superiority over usual medical care25,26. The systematic detection and treatment of delirium has shown small benefits for older surgical patients27.
The exception is the use of clinical prediction rules to identify older people at risk of developing delirium, and this is discussed later under delirium.
The limitations of general care teams discussed above highlights the need for education and training, and suggest that whatever training is currently employed seems to have little effect. Teaching and training is core business for liaison teams and there is evidence that the introduction of liaison services into general hospitals is associated with changes in referral that might be taken to indicate a more informed change of behaviour28. And so, it is likely that their presence, in itself and by clinical contacts, has an educative effect.
However, the best way to deliver more formal training to general care teams remains uncertain. Principles of adult learning which may be usefully incorporated into educational programmes include timely and relevant information based on participant identification of learning needs and integration of new information into existing knowledge base(s) with time for consolidation and appropriate non-judgemental feedback to the individual29.
Case-based discussions that bring immediate relevance, supervision that reinforces knowledge and skills, and audit to evaluate change will be important to effective education. Care pathways can be helpful. This might suggest that an approach which focuses on the needs of specific departments and specialities involving complete clinical teams could be more effective than random teaching sessions for hospital staff and particular professional groups. The circumstances and subject matter should dictate the approach.
Whatever the approach, training time must be built into job plans and the resourcing of liaison teams. The time needed is always underestimated, and when clinical staff are under pressure, training will be relegated to low priority. In one audit of a nurse-led liaison service, 7.5% of time was spent directly on formal education and 33% giving guidance, advice and making recommendations to ward staff30.
Delivery to large hospitals, including night staff, with staff who move through in training, is difficult and a perpetual process. Incorporating mental health into established teaching programmes will give it credence and importance. The presence of liaison teams in general hospitals offers the prospect of mental health being absorbed into the culture of the hospital and not seen as a separate activity just provided by mental health services. The importance of improving the mental health knowledge and skills of general care teams cannot be overestimated because the vast majority of older people admitted to general hospitals with mental health needs will not be seen by specialist liaison teams. The management of non-referred cases will be the ultimate measure of how successfully liaison services have changed the general hospital’s response to mental health.
Delirium
Delirium is the most common non-specific presentation of physical illness among older people and the most common new condition in the hospitalized elderly. It will complicate 5–10% of routine surgery. Delirium present at the time of admission is referred to as prevalent delirium, and that beginning in hospital as incident delirium. The distinction is important when discussing prevention, as 30–40% of incident delirium may be hospital acquired and preventable. Rates of delirium will vary between hospital departments, being highest with the most ill patients (Intensive Care), higher with emergency than elective surgery and higher with more complex conditions.
It is a cause of death, prolonged admission, loss of independent function, high cost and is associated with an increased risk of hospital-acquired complications including incontinence, falls, pressure sores and infection. Estimates from the USA suggest that it affects more than 2.3 million older people each year, is responsible for more than 17.5 million inpatient days and costs over $4 billion (1994 dollars) each year31.
Furthermore, it is now clear that not all delirium resolves, and cognitive impairment persists 12 months after a medical admission when 15% still meet the diagnostic criteria for delirium32. Patients developing delirium during a medical admission are twice as likely to have died, and six-times more likely to have acquired a diagnosis of dementia three years later12. Reversibility seems crucial for outcome. A prospective study of older medical patients found that the 6 and 12 month outcome for delirious people who survive and recover was no different to no-delirium groups in relation to cognition, function or institutional status33.
Onc established, the treatment is that of the underlying condition, with supportive care and management of behavioural and psychotic symptoms34. There is a theoretical basis to developing pharmacological prophylaxis and treatment with cholinesterase inhibitors35,36 and manipulation of the immune system37, but small controlled trials of the former have failed to demonstrate efficacy.
There is compelling evidence for interventions which prevent incident delirium that is closely linked to processes of care. Clinical prediction rules have been described for medical, non-cardiac thoracic surgery and elective orthopaedic populations38–40. These enable people at risk to be identified on admission to hospital and pre-ventative care strategies employed to reduce delirium risk. Because delirium mostly develops within the first seven days of admission or surgery, this approach can concentrate on that period41.
The most developed prevention approach arose from studies of older medical patients, identifying the strongest independent predisposing and precipitating factors that predict incident delirium42,43. These large studies found the relative risk was 9.5-times greater for people with a high-risk predisposing profile, and 8.9-times greater for those with a high-risk precipitant profile, than those with low risk.
This formed the basis of a controlled trial of a preventative intervention involving 852 older medical inpatients, employing a multi-component intervention strategy (The Elder Life Program). The subjects were identified on admission as being intermediate or high risk, and in the intervention arm the incidence of delirium was 34% lower than usual care. The intervention group experienced significantly lower total days with delirium, lower total number of episodes, improved cognitive function in those already cognitively impaired and lower use of sleep medications44.
This intervention was shown to be cost effective for intermediate risk (72% of subjects) but not high risk. Cost of the intervention was offset by savings accrued from treatment intensity, including nursing and diagnostic procedures31.

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