Parkinsonism
Characterized by any combination of: tremor at rest, rigidity, bradykinesia (slowing of movements), hypokinesia (less frequent spontaneous movements), flexed posture, loss of postural reflexes, “freezing” (motor block).
Categories: idiopathic, symptomatic, Parkinson-plus syndromes, heredodegenerative diseases with parkinsonism (Table 115.1).
Core biochemical pathology: decreased dopaminergic neurotransmission in basal ganglia, leading to disinhibition of subthalamic nucleus and medial globus pallidus.
Table 115.1 Classification of Major Parkinsonian Syndromes | ||||
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Rest tremor: 4 to 5 Hz; usually involves limbs, especially distally; also lips, chin, tongue. Disappears with action, but reemerges with maintained posture. Worsened by stress, walking.
Rigidity: increased resistance to passive movement; equal in all directions; often with palpable “cogwheeling.”
Flexed posture: commonly begins in arms, spreads to body.
Bradykinesia: slow movements, difficulty starting movement, loss of automatic movements (arm-swing).
Hypokinesia: reduced amplitude of movement, particularly repetitive movements (“decrementing” finger or toe-tapping).
Akinesia: reduced frequency of movements.
Examples of bradykinesia, hypokinesia, akinesia: hypomimia (decreased facial expression), decreased blinking, loss of gestures, setting motionless, hypophonia, dysarthria, tachyphemia (rapid speech), aprosody (monotonous speech; loss of rhythm of speech), drooling (impaired swallowing), micrographia, impaired fine motor skills, short stride (festinating gait), difficulty rising from seat. Advanced bradykinesia—major impediment in activities of daily living. If feet involved, should stop driving.
Freezing phenomenon (motor block): transient inability to perform active movements. Manifest in legs (gait freezing), eyelids (apraxia of lid opening), speech (palilalia), writing. Lasts several seconds. Triggers: starting to walk, turning, approaching a destination, revolving doors, elevator doors, crossing heavily trafficked streets. Often overcome by visual clues.
Parkinson Disease (PD)
Also known as idiopathic Parkinson disease or primary parkinsonism.
Pathology
Degeneration of neuromelanin-containing neurons in pars compacta of substantia nigra, locus ceruleus; Lewy bodies in surviving neurons.
Epidemiology
About 80% of cases of parkinsonism outlined in Table 115.2. Mean onset age 55, range 20 to 80. M:F ratio 3:2. Prevalence 160:100,000; incidence 20:100,000/year.
Table 115.2 Clues Indicating the Likely Type of Parkinsonism | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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