Pineal Gland Mass
Karen L. Salzman, MD
DIFFERENTIAL DIAGNOSIS
Common
Pineal Cyst
Germinoma
Pineocytoma
Less Common
Teratoma
Pineoblastoma
Rare but Important
Retinoblastoma (Trilateral)
Germ Cell Neoplasms, Malignant NOS
Diffuse Astrocytoma, Low Grade
ESSENTIAL INFORMATION
Helpful Clues for Common Diagnoses
Pineal Cyst
Homogeneous fluid-filled pineal mass
May see rim enhancement
Most are < 1 cm but may be up to 2 cm
Germinoma
Most common germ cell tumor (GCT) & pineal tumor
Homogeneous, hyperdense mass with enhancement, ± CSF seeding
Central, “engulfed” Ca++ classic
Pineocytoma
Demarcated round or lobular mass, typically with Ca++
Strong, homogeneous enhancement
May compress adjacent structures, but no invasion
Helpful Clues for Less Common Diagnoses
Teratoma
2nd most common GCT & pineal tumor
Midline mass containing Ca++, soft tissue, cysts, & fat; variable enhancement
Pineoblastoma
Highly malignant, primitive embryonal tumor of pineal gland
Large, heterogeneous pineal mass with “exploded” peripheral Ca++ & hydrocephalus

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