The Medulla Oblongata

Figure 11-1. Lateral view of the brain at about 7 weeks of gestational age. The medulla is highlighted.

Figure 11-2. Development of the medulla at early (A) and later (B) stages showing the relationships of alar and basal plates and their adult derivatives in the medulla.

Basal and Alar Plates

Maturing neurons of the basal plate of the medulla give rise to the hypoglossal nucleus (somatic efferent [SE] cells), the dorsal motor vagal nucleus and the inferior salivatory nucleus (both contain visceral efferent [VE] cells), and the nucleus ambiguus (somatic efferent [SE] cells) (Fig. 11-2). Caudal to the obex, the hypoglossal and dorsal motor vagal nuclei are small and are found in the central gray surrounding the central canal. Rostral to the obex, all of these nuclei are located medial to the sulcus limitans (Fig. 11-2B).

The cranial nerve nuclei derived from the alar plate in the medulla and their corresponding functional components include the vestibular and cochlear nuclei (somatic afferent [SA]), the solitary nucleus (visceral afferent [VA]), and the spinal trigeminal nucleus (somatic afferent [SA]) (Fig. 11-2). Alar plate neuroblasts caudal to the obex give rise to the gracile and cuneate nuclei. Rostral to the obex, some alar plate cells migrate ventromedially to form the nuclei of the inferior olivary complex.

Concurrent with these developmental events, ascending and descending fibers are traversing the medulla. An especially prominent bundle of axons collects on the anterior (ventral) surface of the medulla to form the pyramids (Fig. 11-2B).

EXTERNAL FEATURES

Anterior Medulla

The anterior (ventral) aspect of the medulla is characterized by an anterior median fissure; two laterally adjacent longitudinal ridges, the pyramids; and the olive (inferior olivary eminence) (Fig. 11-3). The pyramids issue from the basilar pons and extend caudally to the motor (pyramidal) decussation, where about 90% of their fibers cross the midline. Most of the fibers that form the pyramid arise in the motor cortex as corticospinal fibers; consequently, their crossing is called the motor decussation. Rootlets of the hypoglossal nerve (cranial nerve XII) exit the medulla via the preolivary sulcus, a shallow groove located between the pyramid and the olive. The abducens nerve (cranial nerve VI) emerges at the pons-medullary junction, generally in line with the rootlets of cranial nerve XII.

Figure 11-3. Anterior (ventral) view of the brainstem with emphasis on structures of the medulla.

Lateral Medulla

On the lateral aspect of the medulla, a shallow trough, the postolivary sulcus or retroolivary sulcus, is located between the restiform body and the large eminence formed by the underlying inferior olivary nucleus (Fig.11-4A, B). Cranial nerves IX (glossopharyngeal) and X (vagus) emerge from the postolivary sulcus. Caudal rootlets of the vagus have been incorrectly called the medullary, or bulbar, root of the accessory nerve. In actuality, the accessory nerve is made up of axons that arise from cells in the upper levels of the cervical spinal cord (C1 to C5 or C6), ascend through the foramen magnum, coalesce to form the accessory nerve, and then exit the skull via the jugular foramen along with the glossopharyngeal and vagus nerves. Structures served by the accessory nerve receive no innervation from the medulla. The facial nerve (VII), along with its intermediate root, and the vestibulocochlear nerve (VIII) emerge from the posterolateral medulla at the pons-medulla interface. The general region of the exit of the facial and vestibulocochlear nerves is clinically regarded as the cerebellopontine angle. Indeed, a vestibular schwannoma (often incorrectly referred to as an acoustic neuroma) is a tumor of the vestibular portion of the eighth cranial nerve and is a lesion located at the cerebellopontine angle. On the lateral medullary surface caudal to the level of the obex, fibers of the spinal trigeminal nucleus and tract assume a superficial location and form the trigeminal tubercle (tuberculum cinereum) (Fig. 11-4B, C). Rostral to the obex, these trigeminal fibers are located internal to a progressively enlarging restiform body.

Figure 11-4. Anterolateral (A), lateral (B), and posterior (C) views of the medulla. Cranial nerves are indicated by Roman numerals, and the cerebellum has been removed from B and C. The same specimen is used in B and C.

Posterior Medulla

At and caudal to the level of the obex, the posterior surface of the medulla is characterized by the gracile and cuneate fasciculi and their respective tubercles (Fig. 11-4C). These tubercles are formed by the underlying gracile and cuneate nuclei. Rostrolateral to the gracile and cuneate tubercles and forming a prominent elevation on the posterolateral aspect of the medulla is the restiform body. This structure contains a variety of afferent cerebellar fibers and becomes progressively larger as it extends toward the pons-medulla junction. In the caudal pons, fibers of the restiform body join with a much smaller bundle, the juxtarestiform body, to form the inferior cerebellar peduncle.

Vasculature

In general, the blood supply to the entire medulla and to the choroid plexus of the fourth ventricle arises from branches of the vertebral arteries (see Fig. 11-16). The exceptions are the portion of the choroid plexus that extends out of the foramen of Luschka and the adjacent cochlear nuclei; these are served by branches of the anterior inferior cerebellar artery, a branch of the basilar artery. In general, the medial medulla is served by the anterior spinal artery, the anterolateral medulla by small branches from the vertebral artery, and the posterolateral medulla rostral to the obex by the posterior inferior cerebellar artery (PICA). Caudal to the obex, the posterior medulla is served by the posterior spinal artery.

The vascular territory of the anterior spinal artery encompasses the medial lemniscus, hypoglossal root, and corticospinal fibers in the pyramid. Consequently, lesions of this vascular region result in somatosensory and motor deficits reflecting damage to these structures. In similar manner, lesions in the territory of the PICA will damage the anterolateral system and spinal trigeminal tract and nucleus and give rise to deficits reflecting these structures.

INTERNAL ANATOMY OF THE MEDULLA

Summary of Ascending Pathways

The ascending tracts that originate from the spinal cord gray matter (anterolateral system, posterior and anterior spinocerebellar tracts) and from posterior root ganglion cells (gracile and cuneate fasciculi) continue into the medulla (Fig. 11-5). Some anterolateral system fibers terminate in the medulla, as spinoreticular fibers, and others convey pain and temperature input to more rostral levels, including the thalamus, as spinomesencephalic and spinothalamic fibers. Posterior column fibers synapse in the medulla, but the tactile and vibratory information carried by these fibers continues rostrally via the medial lemniscus (Fig. 11-5). Spinocerebellar axons enter the cerebellum through the restiform body (posterior tract) or the superior cerebellar peduncle (anterior tract). Other ascending bundles, such as spinoolivary and spinovestibular fibers, terminate in the medulla.

Figure 11-5. Diagram of the brain showing the location and trajectory of three important pathways and the trigeminal nuclei. The color coding for each is continued in Figures 11-6, 11-8, 11-11, and 11-13.

Summary of Descending Pathways

The descending tracts that originate from the cerebral cortex (corticospinal, Fig. 11-5) and from the midbrain (rubrospinal, tectobulbospinal) and pons (reticulospinal, vestibulospinal) traverse the medulla en route to the spinal cord. The medulla contributes additional fibers to the last two fiber systems. At this level, the medial longitudinal fasciculus contains only descending fibers. The majority of these descending axons influence, either directly or indirectly through interneurons, the discharge patterns of motor neurons in the spinal cord gray matter.

Spinal Cord–Medulla Transition

The spinal cord–medulla transition is characterized by changes that begin at the caudal level of the motor decussation (Figs. 11-6 and 11-7). The spinal cord gray matter is replaced by the motor (crossing of corticospinal fibers) decussation; the central gray matter enlarges; the posterolateral tract (dorsolateral fasciculus) and substantia gelatinosa of the spinal cord merge, respectively, into the spinal trigeminal tract and nucleus; and nuclei characteristic of the medulla appear. The caudal medulla is described in the following sections beginning at the levels of the motor and sensory decussations.

Figure 11-6. Cross section of the medulla at the level of the motor decussation. Correlate with Figure 11-5.

Figure 11-7. A fiber (myelin)–stained cross section of the medulla at the level of the motor decussation. Compare with Figure 11-6. (From Parent A: Carpenter’s Human Neuroanatomy, 9th ed. Philadelphia, Lippincott Williams & Wilkins, 1995.)

Caudal Medulla: Level of the Motor Decussation

At the level of the motor decussation (pyramidal decussation), about 90% of corticospinal fibers cross the anterior midline to form the contralateral lateral corticospinal tract of the cord (Figs. 11-5 to 11-7). Posteriorly, at this level, the gracile and cuneate nuclei first appear in their respective fasciculi (Figs. 11-6 and 11-7). Because the gracile and cuneate fasciculi are collectively called the posterior (or dorsal) columns, their respective nuclei are frequently referred to as the posterior column nuclei. Laterally, the spinal trigeminal tract is visible on the surface of the medulla as the trigeminal tubercle or tuberculum cinereum. Internal to the spinal trigeminal tract is the spinal trigeminal nucleus, pars caudalis