Stroke or head trauma within the preceding three months
Major surgery within the preceding two weeks
History of intracerebral hemorrhage
Systolic blood pressure >185 mm Hg
Diastolic blood pressure >110 mm Hg
Rapidly improving or minor neurologic symptoms and signs
Evidence of subarachnoid hemorrhage
Gastrointestinal or urinary tract bleeding within three weeks
Arterial puncture at a noncompressible site within one week
Seizure at stroke onset
Prothrombin time >15 seconds or INR >1.7
Heparin therapy within two days and elevated PTT
Platelet count < 100,000/mL
Blood glucose <30 mg/dL (2.7 mmol/L) or >400 mg/dL (21.6 mmol/L)
Aggressive treatment necessary to lower blood pressure