Dysmorphic Vertebral Body

Dysmorphic Vertebral Body

Julia Crim, MD



  • Single Vertebral Body

    • Post-Traumatic Deformity

    • Schmorl Node

    • Limbus Vertebra

    • Metastases, Lytic Osseous

  • Multiple but not all Vertebral Bodies

    • Abnormal Segmentation

      • Partial Vertebral Duplication

      • Vertebral Segmentation Failure

      • Klippel-Feil Spectrum

    • Scheuermann Disease

    • Scoliosis

    • Metastases, Lytic Osseous

    • Juvenile Idiopathic Arthritis

    • Neurogenic (Charcot) Arthropathy

    • Post-Radiation Changes

  • Diffusely Abnormal Vertebral Bodies

    • Sickle Cell

    • Osteogenesis Imperfecta

    • Achondroplasia

Less Common

  • Single Vertebral Body

    • Kümmell Disease

    • Osteochondroma

    • Ewing Sarcoma

    • Langerhans Cell Histiocytosis

  • Multiple Vertebral Bodies

    • Osteomyelitis, Pyogenic

    • Osteomyelitis, Granulomatous

  • Diffusely Abnormal Vertebral Bodies

    • Thanatophoric Dwarfism

    • Mucopolysaccharidoses


Key Differential Diagnosis Issues

  • Single vertebrae with abnormal appearance usually post-traumatic

  • 2 or more adjacent vertebrae with abnormal appearance usually segmentation anomaly

Helpful Clues for Common Diagnoses

  • Scheuermann disease causes undulating appearance of vertebral endplates

  • Cushing disease causes cupping deformity of vertebral endplates

  • Infection and neurogenic arthropathy are centered on intervertebral disc and show endplate erosions

  • Juvenile idiopathic arthritis results in vertebral bodies that are tall relative to anteroposterior diameter

  • Kümmell disease distinguished by gas in vertebral body

  • Sickle cell causes “Lincoln Log” deformity

  • Mucopolysaccharidoses and achondroplasia cause “bullet vertebrae” with anterior portion of body small

  • Vertebral bodies near apex of a scoliosis often mildly misshapen

  • Tumors involving only part of vertebral body may cause a dysmorphic appearance due to partial collapse

Aug 7, 2016 | Posted by in NEUROLOGY | Comments Off on Dysmorphic Vertebral Body

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