Esophageal Perforation: Immediate versus Delayed Repair
Rahul Basho
Alex Gitelman
Jeffrey C. Wang
In the United States, more than 500,000 anterior cervical discectomy and fusions were performed from 1990 to 1999 (1). The increasing frequency of this surgical procedure and its relatively low complication rate can give the impression that this is a complication-free procedure. Though the frequency of complications is low, they can have disastrous consequences if not identified and treated in an expedient manner.
Among the potential complications, esophageal perforation is rare but can be associated with a significant mortality among affected individuals. Despite advances in imaging and diagnostic modalities, complications such as mediastinitis, septicemia, and meningitis can occur. Effective treatment is contingent upon a high degree of clinical suspicion, prompt diagnosis, and expedient implementation of treatment by the treating physician.
ANATOMY
The hypopharynx extends from the hyoid bone to the inferior border of the cricoid cartilage. It connects to the trachea ventrally and the esophagus posteriorly at the level of the sixth cervical vertebra (2). The esophagus, approximately 23 to 25 cm in length, ends distally just ventral to the 11th thoracic vertebrae. In relation to surrounding structures, the esophagus rests upon the vertebral bodies and longus colli muscles, which are located posteriorly. It is bordered ventrally by the trachea and flanked on either side by the carotid arteries.
INCIDENCE
The true incidence of esophageal perforation remains unknown and is likely underestimated (3, 4 and 5). Early studies looking at complications from ventral cervical procedures had few references to this injury: Cloward (3) did not mention esophageal perforation in his series, and Tew et al. only had one documented case in their series consisting of 500 cases. Newhouse et al. (6) surveyed all members of the Cervical Spine Research Society and found the reported incidence to be 0.25%. More recent large reviews have indicated that the incidence ranges from 0.2% to 0.4% (8). Studies have shown that esophageal injuries are more likely to occur during surgery for cervical spine trauma than in surgery for degenerative disease (7,9,10). The levels most frequently affected are C5-C6 and C6-C7 due to the fact that these levels are the ones most frequently operated upon.
ETIOLOGY
Esophageal perforations are classified as intraoperative or delayed postoperative complications. Intraoperative esophageal injuries are typically iatrogenic, and their clinical manifestations occur in the early postoperative period. These injuries occur secondary to errant retractor placement, overzealous manual retraction, or direct laceration from use of sharp instruments (2). Delayed postoperative injuries can occur months to years after the original surgery. They are typically due to failure or migration of hardware with resulting
chronic compression. Newhouse et al. (7) noted that the majority of cases recognized after surgery were due to direct irritation of the esophagus by metal, bone, or cement.
chronic compression. Newhouse et al. (7) noted that the majority of cases recognized after surgery were due to direct irritation of the esophagus by metal, bone, or cement.

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