Iatrogenic Disease



Iatrogenic Disease





Selected adverse neurologic reactions due to drugs or diagnostic procedures listed in Table 165.1.








Table 165.1 Adverse Neurologic Reactions Due to Drugs or Procedures for Diagnosis or Therapy

































































Adverse reaction Drug or procedure
Aseptic meningitis Trimethoprim, sulfadiazine, ibuprofen, intravenous immunoglobulin azathioprine, sulindac, tolmetin, naproxen, OKT3
Basal ganglia syndromes (parkinsonism, tardive dyskinesia, other dyskinesias) Butyrophenones, levodopa, phenothiazines, reserpine, tetrabenazine
Brain tumor Immunosuppression (CNS lymphoma)
Radiotherapy (meningioma)
Central pontine myelinolysis Rapid correction of hyponatremia
Encephalopathy Anticonvulsant drugs, cimetidine, corticosteroids, hemodialysis, insulin (hypoglycemia), lithium, methotrexate, metrizamide, monoamine oxidase inhibitors, overhydration (water intoxication), penicillin, pentazocine, propoxyphene, radiotherapy, vincristine
Leukoencephalopathy Methotrexate, radiation, vaccines
Neuroleptic malignant syndrome Neuroleptic drugs
Meningoencephalitis (viral, yeast, toxoplasmosis) Immunosuppression
Malignant hyperthermia Succinylcholine, halothane, others
Myopathies and myoglobinuria Anticonvulsants (with osteomalacia), bacterial toxins with tampon use (toxic shock syndrome), chloroquine, corticosteroids, emetine, epsilon caproic acid, hypophosphatemia, ipecac, kaliuretic diuretics (furosemide, thiazides), licorice (glycyrrhiza), lovastatin, penicillamine, zidovudine
Muscle fibrosis Meperidine, pentazocine
Myotonia Diazacholesterol
Myelopathy Intrathecal injections, delayed arachnoiditis after myelography, radiotherapy, spinal anesthesia, spinal angiography, vaccination
Neuromuscular disorders  
MG Antiepileptic drugs, penicillamine
Other neuromuscular blockade Aminoglycoside antibiotics, succinylcholine
Optic neuropathy Chloroquine, ethambutol, isoniazid, penicillamine, vincristine
Peripheral neuropathy Anticoagulants (nerve compression by hematoma), barbiturates (in acute porphyria), disopyramide, disulfiram, ethambutol, hypophosphatemia, isoniazid, metronidazole, nitrofurantoin, nitrous oxide, perihexilene, phenytoin, procarbazine, vincristine, vitamin B6 excess
Pseudotumor cerebri Corticosteroids, nalidixic acid, tetracycline, vitamin A
Stroke Amphetamines, anticoagulants, cerebral angiography and intraarterial interventional therapies, chiropractic manipulation of neck, induced hypotension for surgery, induced cardiac arrest, insulin-induced hypoglycemia, massage of carotid sinus, open heart surgery and cardiopulmonary bypass, oral contraceptives, overcorrection of hypertension, radiotherapy of neck or cranium

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Jul 27, 2016 | Posted by in NEUROLOGY | Comments Off on Iatrogenic Disease

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