ICBT for Insomnia


1. Symptoms

 Dissatisfaction with sleep quantity or quality and one (or more) of the following symptoms:

  (a) Difficulty initiating sleep

  (b) Difficulty maintaining sleep (frequent awakenings or problems returning to sleep after awakening)

  (c) Early morning awakening with inability to return to sleep

2. Severity

 (a) The sleep difficulty occurs at least 3 nights per week

 (b) The sleep difficulty is present for at least 3 months

 (c) The sleep disturbance causes clinically significant distress or impairment in functioning

3. The sleep difficulty cannot be (solely) attributed to

 (a) Inadequate opportunity for sleep

 (b) Another sleep-wake disorder

 (c) The physiological effects of a substance (drugs or medication)

 (d) Coexisting mental disorders or medical conditions



The DSM-5 is not the only diagnostic classification system which includes insomnia. Insomnia is also incorporated into the International Classification of Diseases (ICD-10; WHO 1992) and in the International Classification of Sleep Disorders (ICSD-2; AASM 2005). The three diagnostic classification systems share the general criteria for insomnia (difficulty initiating or maintaining sleep or non-restorative sleep leading to impairments in daytime functioning), but they vary in the required severity of the symptoms and a number of additional requirements. The DSM criteria seem to be the most sensitive, leading to the highest prevalence rates (Roth et al. 2011).



Prevalence and Consequences


Insomnia is very common. About a third of the people in the general population experiences one or more symptoms of poor sleep. About 10 % reports a full insomnia disorder including daytime consequences (Ohayon 2002). These daytime consequences typically refer to subjectively reported impairments in cognitive and emotional functioning such as fatigue, mood swings, and concentration problems (Kyle et al. 2010). Among other things, these impairments lead to increased health-care use and decreased work productivity which in turn leads to high societal costs (Daley et al. 2009a). It has been estimated that poor sleepers cost society about ten times more than good sleepers (Daley et al. 2009b). Moreover, insomnia might be considered a long-term condition: about half of all patients suffer from insomnia for at least 3 years (Morin et al. 2009).

Insomnia also often co-occurs with other mental or medical conditions. Depression and anxiety are two common comorbid conditions (Staner 2010; Baglioni et al. 2011), but insomnia is also associated with cancer, hypertension, and cardiovascular diseases (e.g., Meng et al. 2012; Redline and Foody 2011; Savard and Morin 2011).


Current Treatments


The high prevalence of insomnia and its related burden of disease call for widely available, high-quality, and effective treatments. Currently insomnia is most often treated with pharmacotherapy either with benzodiazepines or benzodiazepine receptor agonists (Z-drugs: zolpidem, zopiclone, zaleplon). Several meta-analyses have shown that pharmacotherapy is effective in enhancing sleep in the short run, but it has also been demonstrated that there are negative side effects, especially in the elderly, while long-term consequences risks and benefits are still unknown (Buscemi et al. 2007; Glass et al. 2005).

Various non-pharmacological treatments have been developed as alternatives. These non-pharmacological treatments can be classified as educational (psychoeducation, sleep hygiene), behavioral (relaxation, sleep restriction, stimulus control, paradoxical intention), or cognitive (identifying and challenging dysfunctional thought about sleep; Edinger and Means 2005; Espie 2006; Morin and Espie 2003). Since the 1990s, it has become popular to offer those treatments in (different) combinations. These combinations are referred to as cognitive-behavioral therapy for insomnia (CBTI). See Table 8.2 for an overview of the core components. Next to those core components, the treatment might include relaxation exercises, paradoxical intention (in which the patient is instructed to stay awake during the night), mindfulness exercises, or problem-solving strategies.


Table 8.2
Core components of CBTI



























Component

Description

Sleep education

Information about what instigates sleep, the function of sleep, the normal range of hours of sleep for different age groups, and information about sleep disorders and insomnia

Sleep hygiene

Information about everyday behavior and habits that might promote, or interfere, with good sleep. This usually includes information about lifestyle (e.g., food, caffeine, alcohol, stress) and bedroom (e.g., temperature, light, mattress)

Stimulus control

Patients are taught to associate their bed with sleep again (instead of lying awake). This includes to go to bed and get out of bed at the same time each day, to use the bed for sleep and sex only but not for other activities such as reading or watching television, and to get out of bed in case of lying awake for more than 15 or 30 min. The fixed hours for going to bed and getting up in the morning helps the circadian rhythm to stabilize and facilitate a more pronounced difference between sleep and wakefulness

Sleep restriction

Patients restrict their time in bed. The rationale is that patients sleep fewer hours and become more tired than usual. As a consequence, they have less difficulty falling and staying asleep. Sleep restriction can also be viewed and explained as exposure therapy – exposure to the fear of being very tired during the day

Usually the number of hours in bed is restricted to the average numbers of hours a patient actually slept in the week prior to starting the sleep restriction. In case the patient actually sleeps for 80–90 % of those limited number of hours, for a prespecified number of days, the sleep window is extended by 15 or 30 min. This continues until the desired number of hours is reached

Cognitive reappraisal

Patients are taught to identify and challenge their misconceptions about sleep (i.e., “I need 8 h of sleep to perform well during the next day”). It might also be aimed at identifying and challenging other thoughts that keep the patient awake at night and thus providing a more general form of cognitive therapy

Unfortunately, not many patients receive CBTI. One reason is that less than half of all the insomnia patients seek help (Morin et al. 2006a). People with insomnia usually believe that medication is the only existing treatment option. They may be reluctant to take sleep medication and therefore reluctant to seek help. A second reason is that CBT for insomnia is not widely available. Moreover, GPs seldom refer to available psychological services for insomnia even when they do exist (Everitt et al. 2014). Offering CBT through the Internet may help overcome these issues.



ICBT Programs for Insomnia


As early as in 1979, it was recognized that insomnia treatment might also be delivered in self-help formats (Alperson and Biglan 1979). During the following 30 years, several self-help programs have been developed in different formats such as books, videos, and audiotapes (e.g., Morin et al. 2005; Riedel et al. 1995). This means that patients receive materials in which the different components of cognitive-behavioral therapy are explained. They are stimulated to practice the established CBTI techniques themselves or with brief therapist support.

The first study on Internet-delivered self-help for insomnia appeared in 2004 (Ström et al. 2004). To date we identified ten different programs which have published data on the effectiveness of the program: nine for adult patients with insomnia (Blom et al. 2015a; Espie et al. 2012; Kaldo et al. 2015a; Lancee et al. 2012; Ritterband et al. 2009; Ström et al. 2004; Suzuki et al. 2008; Van Straten et al. 2014; Vincent and Lewycky 2009) and one for adolescent patients (De Bruin et al. 2014).

The ten programs all include the core CBTI components as described in Table 8.2, and some include additional components, e.g., audio files for relaxation and stress management techniques. Even though the content of the programs is not that different, the way the treatments are presented does vary quite a lot. The treatment by Suzuki offers all the CBT elements, but patients can choose which of those they want to try out (at least three). The treatment of De Bruin is offered during fixed weekly online consultations. The treatments by Blom and Kaldo have both fixed and optional elements, with flexible and active online therapist support. The remaining treatments are fixed structured programs which the patients can work through at their own pace. Some of the programs are mostly text based (e.g., Blom, De Bruin, Lancee, Ström, Kaldo, Van Straten), while others make more use of audiovisual clips (e.g., Vincent) or use an array of different elements to make the intervention more attractive. Examples of these elements are quizzes, games, animations, and a virtual therapist (e.g., Espie, Ritterband). The rationale behind a more interactive design, next to offering patients a more pleasurable experience, is to promote better understanding of the information. It is also suggested that it will retain patients in the intervention.

The interventions also vary in the way patients are supported. This varied from no support at all (Lancee, Vincent) to automated support (Espie, Ritterband, Ström, Suzuki) and weekly personal feedback from a coach or therapist (Blom, De Bruin, Van Straten, Kaldo). Support is aimed at helping patients through the program and exercises (i.e., providing optimal sleep windows) and to encourage patients to continue. The automated support was personalized and based on bed times and sleep estimates provided by patients in their sleep diary.


Case Description


Farah is a 34-year-old woman with insomnia disorder. Her sleeping problems started when her child, now 3 years old, was a baby and needed feeding several times per night. When the baby grew older and started sleeping through most nights, Farah kept waking up three to four times per night and had trouble going back to sleep. After her parental leave, Farah went back to her job as a manager at a construction company. The work entails long hours and a high level of stress. Farah started having trouble falling asleep, in addition to her frequent nighttime awakenings. She found it hard to relax in the evening. She often checked her email late in the evening to get a head start on next day’s work. Her mind was constantly active solving problems, thinking about work and planning their everyday life, making her mentally aroused when trying to sleep. She started worrying a lot about not sleeping and the ramifications of that for her health and performance at work and as a parent. The worrying made it even harder to fall asleep – a catch 22! She was too tired to meet friends and exercise, something she used to do regularly prior to her sleeping problems. Farah has started using sleep medication in order to fall asleep. Her general practitioner (GP) has told her not to use it too frequently, for fear of habituation, and she takes them two or three times per week when she is desperate to sleep. They help her go to sleep, but she still wakes up during the night. It is not a satisfactory solution.

Farah talks to her GP about her issues, and the GP deems online treatment to be suitable for her. He refers her to a mental health service which offers online CBT for insomnia. After filling out an online sleep diary for 1 week, her treatment starts.

Farah logs on to the treatment Internet site and is greeted by a welcome message from her personal online psychologist. The treatment is divided into several chapters, which she can access sequentially, after completing the previous chapter. The treatment consists of educational text to read about insomnia and CBT for insomnia, questions to answer at the end of each chapter on theory and how it applies to her situation, assignments on how to work through the CBT interventions, work sheets to fill out, and a sleep diary that is to be filled out daily throughout treatment.

When Farah has finished a chapter, her writings and answers are automatically sent to her psychologist. The psychologist logs on to the site and looks into Farah’s sleep diary and her writings. The psychologist then gets back to her with advice, answers to questions, and encouragement. Farah is expected to complete on average one chapter per week and can send messages to her psychologist whenever she wants. After a couple of weeks’ treatment, Farah gets a cold, and at the same time her workload increases dramatically due to a colleague’s sick leave. As a result she stops focusing on the ICBT and forgets to log on to the site. When Farah hasn’t been heard from for 1 week, her psychologist sends an online message, asking her how she is doing and motivating her to continue with the treatment. After that, Farah is back on track and continues with the next chapter. She will need another two text messages to remind her in the coming weeks, but she always responds quickly and makes it though the treatment chapters on time.

The treatment focuses on behavioral changes such as sleep restriction, stimulus control, and evening routines. Farah struggles with sleep restriction, since it means she has to stay awake until one in the morning the first week and get up at 6 o’clock. The most difficult part is staying awake in the early evening after putting her child to bed. After online consultation with the psychologist, she decides to start a new evening routine and she asks her husband to support her to stick to the routine. It means that she takes a walk after putting her child to bed, that she and her husband watch some television together, and that she takes a bath before going to bed. Quite soon after she starts adhering to the sleep restriction schedule, she notices that she wakes up less often which encourages her further to stick to the routine. The treatment also encompasses cognitive reappraisal, stress management, and how to cope with, and prevent, sleepiness and fatigue. For example, Farah is encouraged to talk to her manager about reducing her workload, and she takes up running again. She also starts meeting her friends every now and then, even if she feels tired. At the end of the treatment, she makes a plan for the future – how to continue with interventions and look for warning signs of relapse.

When Farah has worked through the complete treatment, her insomnia severity has dropped from severe to mild. At the start it took her around 40 min to fall asleep after going to bed, but this decreased to only 10 min. She also wakes up less frequently and worries less about her sleep problems. Even though her actual sleep time has not increased by much, she feels that her sleep quality is much better and daytime fatigue is much less. She doesn’t use any sleep medication anymore. She believes her sleep time will increase a bit more when she continues with her sleep restriction schedule for a few more weeks after the treatment.


ICBT for Insomnia: Does It Work?



Relevant Insomnia Outcomes


One of the challenges in insomnia research is that there is no generally accepted primary outcome measure. First, some researchers prefer to obtain objective sleep data (e.g., polysomnography or actigraphy), while others prefer subjective sleep data (sleep diary). Even though objective and subjective data are correlated, they usually lead to different results. Second, sleep is usually expressed in a number of different estimates: sleep onset latency (SOL) which is the number of minutes it takes to fall asleep after switching of the light, number of awakenings (NWAK) during the night, time being awake after sleep onset (WASO), the total sleep time (TST), and the sleep efficiency (SE) which is the percentage of time sleeping while being in bed. Third, some researchers prefer to ask patients directly about their insomnia severity and their sleep quality instead of using sleep diaries. Two often used instruments are the Pittsburgh Sleep Quality Index (PSQI; Buysse et al. 1989) and the Insomnia Severity Index (ISI; Morin et al. 2011; Thorndike et al. 2011). They are validated and offer cutoffs to identify patients with clinically significant symptoms of insomnia. In summary, all the different variables measure different aspects of sleep. Sleep improvements are therefore usually expressed not in one but in a number of different estimates.


Face-to-Face CBT


Several excellent (systematic) reviews have been written on face-to-face CBTI and have concluded that CBTI is effective, has longer-lasting effects than medication, and should be the preferred treatment for insomnia (Montgomery and Dennis 2004; Morin et al. 2006b; Murtagh and Greenwood 1995). This means that people usually fall asleep quicker and are less often awake during the night even though their total number of hours asleep generally only improve modestly. However, since sleep is less fragmented, patients tend to report large improvements on insomnia severity and sleep quality.


Internet-Based CBT


Three meta-analyses have been performed on self-help interventions for insomnia. The first included all self-help formats (e.g., books, audio) and encompassed only one study on an Internet intervention (Van Straten and Cuijpers 2009). This meta-analysis was updated in 2015 (Yan-Yee Ho et al. 2015). The third one specifically focused on the effectiveness of computerized CBT for insomnia (Cheng and Dizon 2012). Six Internet programs were identified in these meta-analyses. The overall conclusion was that Internet-based self-help is effective in improving sleep with moderate effect sizes.

After the publication of the meta-analyses, effectiveness data was published on four new Internet CBT programs (Blom et al. 2015b; De Bruin et al. 2014; Van Straten et al. 2014; Kaldo et al. 2015b). This means that there are currently ten Internet programs for insomnia: nine for adults and one for adolescents. Seven of the ten studies demonstrating effectiveness used a wait-list or treatment-as-usual comparison group, one used a placebo control group (Kaldo et al. 2015a), while two studies compared their online treatment to a face-to-face group therapy (Blom et al. 2015a; De Bruin et al. 2014). Table 8.3 provides a summary of the data of the ten trials.


Table 8.3
Summary of effectiveness of the ten identified online CBT programs for insomnia

















































































































                 
Posttest between group effect sizes (Cohen’s d)d

Author

Country

Insomnia definition

Intervention

Control

Support

Weeks

N

Full adherence

SOL

TST

SE

WASO

NWAK

Studies comparing the Internet treatment against wait-list or treatment-as-usual

Ström et al. (2004)

Sweden

≥30 min awake, ≥3 nights a week, ≥3 months + daytime problem

Core CBT

WL

Automated + max 2 e-mails

5

109

80 %

0.34

0.01

0.20

−0.04

0.24

Suzuki et al. (2008)

Japan

A desire to improve sleep

Sleep education + sleep hygiene. Then patients can choose from other CBT components

WL

Automated personalized messages

2

43


0.33

0.09

0.23



Ritterband et al. (2009)

USA

Sleep difficulties for ≥3 nights a week, ≥6 months + daytime problem

Core CBT

WL

Automated

6

45

91 %c

0.99

0.41

1.23

0.94

0.71

Vincent and Lewycky (2009)

Canada

≥30 min awake, ≥4 nights a week, ≥6 months + daytime problem

Core CBT + relaxation

WL

None

5

118

68 %

0.50

0.24

0.23

0.13

0.68

Espie et al. (2012)

Scotland

Sleep difficulties for ≥3 nights a week, ≥3 months + daytime problem

Core CBT + imagery + articulatory suppression + mindfulness + social community of users

TAUa

Virtual therapist. Automated support tailored on severity and improvements over time

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Mar 10, 2017 | Posted by in PSYCHOLOGY | Comments Off on ICBT for Insomnia

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