ICBT in Psychiatry: Generalised Anxiety Disorder

 

Educational material

Applied relaxation or other relaxation/de-arousal intervention

Cognitive restructuring for thoughts, beliefs and meta-cognitive beliefs

Scheduled worry time

Problem solving

Worry exposure/behavioural experiments

Interpersonal problem solving and/or communication skills training

Sleep management

Behavioural activation/activity scheduling

Mindfulness

Relapse prevention

Carlbring et al. (2011)

x

(x)*

x

x

x

x
 
(x)*

(x)*
 
x

Dear et al. (2011a)

x

x

x

(x)*

(x)*

X

(x)*

(x)*

x
 
x

Draper et al. (2008)

x

x

x
 
x

x
   
x

x

Johnston et al. (2011)

x

x

x

(x)*

(x)*

x

(x)*

(x)*

x
 
x

Newby et al. (2013)

x

x

x
 
x

x
  
x
 
x

Paxling et al. (2011)

x

x

x

x

x

x

x

x
  
x

Titov et al. (2013)

x

x

x

(x)*

(x)*

x

(x)*

(x)*

x
 
x

Titov et al. (2011)

x

x

x

(x)*

(x)*

x

(x)*

(x)*

x
 
x

Titov et al. (2009a)

x

x

x

(x)*

(x)*

x

(x)*

(x)*

x
 
x


(x)* Indicates the treatment strategy was administered to participants who the therapist thought would benefit from them





Effects in Research and Clinic: Results of Research Trials and Clinical Use


The studies described below report published outcomes for ICBT interventions for GAD (see Table 5.2). Studies were included if they evaluated interventions that were designed specifically for treating GAD or designed to target symptoms of GAD in addition to symptoms of other anxiety disorders or depression. All studies included were conducted in either Sweden or Australia. Before discussing the results of these studies, it is helpful to consider issues in diagnosis and measurement of symptoms of GAD.


Table 5.2
Studies of Internet-delivered cognitive behavioural treatments for GAD




















































































































































































































































Authors (country)

Design
 
Sample

Results
 
Design conditions (n)

Primary outcome measures

Intervention components

Treatment duration

Guidance

N

Diagnostic tool/criteria

Analysis

Total therapist contact

Within-group ES

(pre-post d)

Within-group ES

(pre-follow-up d) (duration)

Draper et al. (2008) (Australia)

Research open trial

1. TG ICBT

(a) GADQ-IV, (b) PSWQ

11 CBT-based online lessons; occasional telephone calls

11 weeks

Self-guided

3

SCID-IV

ITT/completer

Occasional phone calls to facilitate engagement



Titov et al. (2009a) (Australia)

Research RCT

1. TG ICBT

2. WLC

(a) GAD-7, (b) PSWQ

6 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls; online discussion forum

8 weeks

Therapist guided

45

MINI

ITT

130 min

1. (a) 1.67; (b) 0.98

2. (a) 0.34; (b) 0.02


Robinson et al. (2010) (Australia)

Research RCT

1. TG ICBT

2. CG ICBT

3. WLC

(a) GAD-7, (b) PSWQ

6 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls; automated emails; online discussion forum

10 weeks

Therapist guided

145

MINI

ITT

TG ICBT 81 min; CG ICBT 75 min

1. (a) 1.55; (b) 1.16

2. (a) 1.73; (b) 1.07

3. (a) 0.38; (b) 0.14

1. a) 1.48;b) 1.42

2. a) 1.61;b) 0.97


(3 months)

Titov et al. (2010) (Australia)

Research RCT

1. TD TG ICBT

2. WLC

(a) GAD-7, (b) PSWQ

6 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls; online discussion forum

8 weeks

Therapist guided

78

MINI

ITT

46 min

1. a) 0.81;b) 0.60

2. a) -0.01; b) 0.21

1. (a) 0.73; (b).79

(3 months)

Johnston et al. (2010) (Australia)

Research RCT

1. TG ICBT

2. CG ICBT

3. WLC

(a) GAD-7, (b) PSWQ

8 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls; automated emails; online discussion forum

10 weeks

Therapist guided

131

MINI

ITT

TG ICBT 70 min; CG ICBT 69 min

1. (a) 0.71; (b) 0.81

2. (a) 1.06; (b) 1.17

3. (a) 0.15; (b) 0.02

1. (a) 0.57;(b) 0.81

2. (a) 1.18;(b) 1.12


(3 months)

Carlbring et al. (2011) (Sweden)

Research RCT

1. IT TG ICBT

2. AC

(a) BAI, (b) MADRS-S

Participants prescribed 6 to 10 CBT-based online modules based on existing ICBT interventions for panic disorder, social phobia, GAD and depression

10 weeks

Therapist guided

54

SCID-I

ITT

85 min

1. (a) 1.12; (b) 1.21

2. (a) 0.44; (b) 0.46

1. (a) 1.23;(b) 1.31

(Entire sample 2 years)

Titov et al. (2011) (Australia)

Research RCT

1. TD TG ICBT

2. WLC

(a) GAD-7, (b) PSWQ

8 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls; online discussion forum

10 weeks

Therapist guided

74

MINI

ITT

85 min

1. (a) 0.92; (b) 0.68

2. (a) 0.22; (b) -0.08

1. (a) 0.94;(b) 0.63

(3 months)

Dear et al. (2011a) (Australia)

Research open trial

1. TD TG ICBT

(a) GAD-7, (b) PSWQ

5 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls; online discussion forum

8 weeks

Therapist guided

32

MINI

ITT

45 min

1. (a) 1.06; (b) 0.84

1. (a) 0.95;(b) 0.90

(3 months)

Paxling et al. (2011) (Sweden)

Research RCT

1. TG ICBT

2. WLC

(a) PSWQ

8 online treatment modules based on Paxling et al. (2011), weekly homework assignments, weekly secure messaging with therapist

8 weeks

Therapist guided

89

GADQ-IV

ITT

113 min

1. (a) 1.08

2. (a) -0.01

1. (a) 1.66

(12 months); (a) 1.40 (3 years)

Klein et al. (2011) (Australia)

Clinical open trial

1. SG ICBT

(a) GAD-CDSR

12 CBT-based online lessons; homework tasks, delivered in a fully automated system

12 weeks

Self-guided

88

Online diagnostic system/at least subclinical levels of GAD

Completers (88/704)

Nil

(a) 1.22


Andersson et al. (2012) (Sweden)

Research RCT

1. TG ICBT

2. TG IPDT

3. WLC

(a) PSWQ

1. 8 online treatment modules based on Paxling et al. (2011), weekly homework assignments, weekly secure messaging with therapist

2. 8 online chapters based on Make the Leap, self-help book and recommended writing assignments, weekly secure messaging with therapist

8 weeks

Therapist guided

81

SCID-I

ITT

TG ICBT 92 min; IPDT 113 min

1. (a) 0.87

2. (a) 1.16

3. (a) 0.72

1. (a) 1.88

2. (a) 1.92

3. –

(18 months)

Mewton et al. (2012) (Australia)

Clinical open trial

1. TG ICBT

(a) GAD-7

6 CBT-based online lessons; homework tasks, unspecified support from external health professional

11 weeks

Therapist guided

588

N/A

Completers (324/588)

Not described

(a) 0.91


Kirkpatrick et al. (2013) (Australia)

Clinical open trial

1. TG ICBT

(a) GAD-7, (b) PHQ-9

5 CBT-based online lessons; homework assignments; additional written resources; weekly telephone calls

8 weeks

Therapist guided

10

GAD-7 ≥ 5

ITT

Not described

1. (a) 1.07; (b) 1.76

1. (a) 1.61;(b) 2.17

(2 months)

Newby et al. (2013) (Australia)

Research RCT

1. TD TG ICBT

2. WLC

(a) GAD-7, (b) PSWQ

6 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls

8 weeks

Therapist guided

99

MINI

ITT

24 min

1. (a) 0.96; (b) 0.87

2. (a) 0.07; (b) 0.01

Not reported

(3 months)

Newby et al. (2013) (Australia)

Clinical open trial

1. TD TG ICBT

(a) GAD-7, (b) PHQ-9

6 CBT-based online lessons; homework tasks, unspecified support from external health professional

8 weeks

Therapist guided

136

N/A

ITT

Not described

1. (a) 1.05; (b) 0.94


Titov et al. (2013, 2014) (Australia)

Research RCT

1. SGE ICBT

2. SG ICBT

3. WLC

(a) GAD-7, (b) PHQ-9

5 CBT-based online lessons; homework assignments; additional written resources; weekly secure messaging or telephone calls

8 weeks

Self-guided

257

GAD-7 ≥ 8, or PHQ-9 > 10, or MINI-SPIN ≥5, or ANSQ ≥1

ITT

Nil

1. (a) 1.08; (b) 0.96

2. (a) 0.76; (b) 0.68

3. (a) 0.14; (b) 0.02

1. (a) 1.08;(b) 1.10

2. (a) 1.01;(b) 0.98

(12 months)


AC Attention Control, ANSQ Autonomic Nervous System Questionnaire, CG IPDT Coach-Guided IPDT: Internet-Based Psychodynamic Treatment Group, Completer Analysis restricted to completers only, ES Effect Size, GAD-7 Generalized Anxiety Disorder Scale, 7-Item Scale, GAD-CDSR GAD Clinical Disorder Severity Rating for Online Diagnostic System, GADQ-IV Generalized Anxiety Disorder Questionnaire, IT TG ICBT Individually Tailored Therapist-Guided ICBT, MINI Mini International Neuropsychiatric Interview Version 5.0.0, MINI-SPIN MINI Social Phobia Inventory, PHQ-9 Patient Health Questionnaire-9-Item, PSWQ Penn State Worry Questionnaire, SCID-I Structured Clinical Interview for DSM-IV Axis 1 Disorders Research Version, SCID-IV Structured Clinical Interview for DSM-IV, SG ICBT Self-Guided ICBT, SGE ICBT Self-Guided ICBT with Automated Email Reminders, TD Transdiagnostic, TG ICBT Therapist-Guided Internet-Based Cognitive Behaviour Therapy, IPDT Internet-Based Psychodynamic Treatment Group, ITT Intention to Treat, WLC Waitlist Control Group


Diagnosis and Measurement of GAD


It should be noted that several strategies have been used in studies of ICBT for GAD to identify people with clinical or subclinical levels of GAD. These include manually administered clinical interviews, automated structured diagnostic interviews, or cut-off scores based on responses to standardised questionnaires which are usually administered online. Where possible, these different criteria are noted below.

With respect to measurement of symptoms and severity of GAD in trials of ICBT, most studies have reported the use of the Penn State Worry Questionnaire (PSWQ) (Meyer et al. 1990) or the Generalized Anxiety Disorder 7-Item Scale (GAD-7) (Spitzer et al. 2006). The PSWQ consists of 16 items and is considered a valid clinical measure of worry characteristic of GAD. Early psychometric evaluations revealed the PSWQ had high internal consistency and temporal stability (Meyer et al. 1990) and was able to differentiate patients with GAD from those with other anxiety disorders (Brown et al. 1992). The GAD-7 is an increasingly popular measure of symptoms of GAD, which comprises seven items from the DSM-IV criteria for GAD. Psychometric evaluations of the GAD-7 indicate it is sufficiently sensitive to detect GAD, panic disorder, social phobia and post-traumatic stress disorder. A recent psychometric comparison of the PSWQ and GAD-7 revealed a moderate correlation between the two scales, and both were sensitive to change, although the GAD-7 appeared to be more sensitive and may, therefore, confer some advantages in clinical work (Dear et al. 2011b).

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Mar 10, 2017 | Posted by in PSYCHOLOGY | Comments Off on ICBT in Psychiatry: Generalised Anxiety Disorder

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