Neuropathic Pain
Estimated to affect 1% of general population, 10% of people with diabetic neuropathy.
Definitions
Neurogenic pain: resulting from non-inflammatory dysfunction of peripheral or central nervous system, without peripheral nociceptor stimulation or trauma.
Primary nociceptive pain: process injuring tissue stimulates pain receptors.
Neurogenic Pain Syndromes
Deafferentation pain: follows interruption of primary afferent nociceptive pathways; term used most often for syndromes that follow CNS injury.
Neuropathic pain: pain associated with peripheral nervous system injury.
Neuralgia: pain in distribution of single peripheral nerve.
Other syndromes: complex regional pain syndrome (CRPS) type I (formerly reflex sympathetic dystrophy), type II (formerly causalgia); thalamic pain syndrome; trigeminal neuralgia; post-herpetic neuralgia.
Etiology
Most common cause is diabetes mellitus. Others include Sjögren syndrome, alcohol or drug toxicity, AIDS, hyperlipidemia, amyloidosis, Tangier disease, Fabry disease.
Clinical Features
Variable pain quality, including burning, aching, electric, stabbing, lancinating.
Related posts:
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
