Schizophrenia



Schizophrenia





Abnormalities in perception of reality, form, and content of thoughts and speech, emotional deficits, leading to disturbed sense of self, social dysfunction, apathy, peculiar behavior. Symptom onset usually in late adolescence, early adulthood. Prevalence about 1% of all people worldwide.



  • Psychosis: failure to distinguish between reality and thoughts (hallucinations, delusions). A feature of schizophrenia; also present in many medical diseases (Table 161.1), other psychiatric conditions (e.g., bipolar disorder, depression, dementia, substance use, acute and chronic post-traumatic stress disorders).









Table 161.1 Differential Diagnosis of Psychosis: Medical and Neurologic Disorders
































Epilepsy Especially temporal lobe epilepsy
Neoplasm Especially frontal, temporal lobe tumors
Cerebrovascular disease  
Traumatic brain injury  
Infectious AIDS (progressive multifocal leukoencephalopathy, AIDS dementia, CNS lymphoma, toxoplasmosis, cryptococcal meningitis); herpes encephalitis; neurosyphilis
Inflammatory Systemic lupus erythematosus, neurosarcoidosis
Metabolic Acute intermittent porphyria, vitamin B12 deficiency, homocystinuria, pellagra, Wilson disease
Degenerative Creutzfeldt-Jakob disease, frontotemporal dementia, Huntington disease, metachromatic leukodystrophy
Drug-related Alcohol (delirium tremens, hallucinosis, Wernicke-Korsakoff syndrome), CNS depressants (barbiturate withdrawal), hallucinogens (LSD, phencyclidine [PCP]), stimulants (amphetamines, cocaine), corticosteroids
Other toxins Carbon monoxide poisoning, heavy metal poisoning

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Jul 27, 2016 | Posted by in NEUROLOGY | Comments Off on Schizophrenia

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