Spinal Cord Injury: Assessment and Neurologic Classification

Spinal Cord Injury: Assessment and Neurologic Classification
Perry Dhaliwal
Lori Anne Archer
Steven Casha
Among the many concerns in the initial management of a trauma patient, spinal cord injury presents a significant challenge to the patient as well as care providers. A review of epidemiologic data suggests that the incidence of spinal cord injury in North America is approximately 51 cases per million per year and the prevalence is estimated at 755 cases per million per year (1). Though the number of cases may be small, it is clear that each of these patients will require intensive management in the acute and chronic phases of their illness (2). Moreover, the severity of the injury correlates with the potential for recovery (3). Thus, early recognition of signs of spinal cord injury and efficacious management of these patients are crucial elements in ensuring a successful outcome.
From the initial management of the patient in the field to the early management in hospital, the possibility of spinal cord injury and preservation of spinal cord function are of utmost importance. In this chapter, details on the early management of patients with spinal cord injury are highlighted. Furthermore, the classification of spinal cord injury and the presentation of classic spinal cord injury syndromes are discussed.
INITIAL MANAGEMENT
The initial management of any trauma patient involves protection of airway, breathing, and circulation. Following initial stabilization, a preliminary neurologic examination should be performed to assess for any signs of injury to the central nervous system. This preliminary neurologic examination involves palpation of the vertebral column to identify step deformities as well as a digital rectal examination to assess for deep sensation and control of the anal sphincter. A more detailed neurologic examination should be performed once the full trauma assessment has been completed.
A patient with spinal cord injury may also have cardiovascular abnormalities, which are important to recognize early. Patients with cervical or high thoracic lesions may have loss of sympathetic innervation and unopposed parasympathetic signaling of cardiovascular functions (4). This combination of autonomic dysfunction may manifest as hypotension (due to loss of vascular tone), bradycardia, and relative hypovolemia. Prolonged hypotension may lead to injury of other organ systems and may exacerbate secondary injury of the spinal cord (5). These patients require diligent management through the use of fluid resuscitation and vasopressors to support their blood pressure (6). In addition to hemodynamic instability, patients with spinal cord injury have a high incidence of respiratory illness. One study suggests that the incidence of respiratory complications in the acute period following spinal cord injury is 50% (7). Respiratory illness also accounts for a large proportion of deaths observed in the first year following spinal cord injury (8). For this reason, protection of the patient’s airway from secretions and gastric contents during the acute period of injury may prevent many of the respiratory complications that occur.
Aside from the initial efforts at resuscitation, current management guidelines mandate proper immobilization and positioning of the patient (9). All patients with significant trauma, loss of consciousness, pain along the vertebral column, and/or neurologic symptoms should be treated as having a spinal cord injury until proof exists to the contrary. Immobilization of the cervical spine should be maintained using a cervical collar. The patient should also be kept supine, and any transfers should be performed using a backboard. Note, however, that the patient should be removed from the backboard as soon as possible to prevent the formation of decubitus ulcers.
DIAGNOSTIC IMAGING
Imaging studies are of crucial importance to those physicians responsible for managing a patient’s spinal cord injury. However, the timing and extent of imaging is dependent on the extent of traumatic injury to the patient as well as the neurologic examination. Several guidelines have emerged, which serve to inform decisions around the need for diagnostic imaging.
There are two commonly used decision paradigms for determining whether a patient requires radiography of the cervical spine—the Canadian C-spine rules (10) and the National Emergency X-Radiography Utilization Study (NEXUS) Low-Risk Criteria (11). The first bases the decision on risk factors for cervical spine injury (see Fig. 40.1). Another set of guidelines uses five criteria to decide on the likelihood of cervical spine injury following blunt trauma (see Table 40.1). Though both criteria have been validated and demonstrate excellent interrater reliability, a comparison (12) of the guidelines suggests that the Canadian C-spine rules may be more sensitive and specific for cervical spine injury in patients who are alert. Though there is evidence (13) that clinical examination alone will miss some cervical spine injuries, the current guidelines for clearing of the cervical spine remain the same in a patient who is awake, alert, and nonintoxicated and who does not have any distracting injuries (14). If the cervical spine cannot be cleared based on the aforementioned criteria, further diagnostic imaging is warranted. Though plain x-ray was the standard radiographic evaluation, an overwhelming body of literature (15) has demonstrated that plain x-rays have a sensitivity of 52% whereas CT scans of the cervical spine have a sensitivity of 98% in detecting traumatic changes. Thus, the current recommendation is that CT scanning of the cervical spine should be used to rule out C-spine injury over plain cervical x-rays in the acute setting although several centers continue to start with plain x-rays and use CT scan in a more selective manner.
Figure 40.1. The Canadian C-spine rules for determining need for imaging of the cervical spine.
TABLE 40.1 NEXUS Criteria for Evaluation of Cervical Spine Injuriesa

No posterior midline cervical spine tenderness

No evidence of intoxication

A normal level of alertness

No focal neurologic deficit

No painful distracting injuries

aIf patients meet all of the listed criteria, then cervical

radiography is not indicated.

Imaging of the obtunded or comatose patient remains a significant challenge. Given its excellent sensitivity in detecting injury, initial investigations for patients who are obtunded or comatose should begin with a CT scan of the cervical spine (16). If there is evidence of injury, then an MRI is warranted to further assess the neural elements given the lack of a reliable neurologic physical evaluation. A more challenging scenario, however, is where the CT scan of the cervical spine does not identify any injury in the obtunded or comatose patient. In this scenario, there is tremendous controversy about the need for further imaging. The practice of obtaining flexion/extension views of the cervical spine in an obtunded patient is felt to add little information and is considered dangerous by some (9,17). The need for magnetic resonance imaging, however, has not been well established (13). Some authors have demonstrated significant injuries based on MRI whereas others have not found MRI to be as useful (13,18, 19 and 20). Factors such as mechanism of injury, neurologic examination, and safety of obtaining an MRI in an obtunded patient all warrant consideration before this form of imaging is performed.
Though the guidelines for imaging of the cervical spine have been established, decision trees for imaging of the thoracic and lumbar spine are not as well prescribed. Currently, it is accepted by most that certain mechanisms of injury and clinical presentations increase the likelihood of thoracolumbar fractures (21). High-velocity impact or collisions, falls from >10 feet, and generalized tonic-clonic seizures are all recognized as mechanistic risk factors for the development of thoracolumbar fractures. Clinical features such as intoxication, head injury, distracting injuries, neurologic deficit, and fractures elsewhere in the spine are recognized risk factors for having fractures of the thoracolumbar spine. Thus, all patients with the aforementioned mechanisms of injury or clinical presentation warrant further investigation with radiography. Asymptomatic patients do not require further investigation. The gold standard for imaging of the thoracolumbar spine has been plain x-ray radiography (16). However, with the increasing use of CT scans for imaging of the chest and abdomen, reformatted CT images of the thoracolumbar spine have come into favor for evaluation of injury. There are currently no standardized guidelines for the use of CT scans in imaging of the thoracolumbar spine following blunt trauma though a recent consensus statement (22) considers the need in the context of the need for imaging of other areas of injury. The indications (16) for magnetic resonance imaging of the thoracolumbar spine include (a) the presence of neurologic deficits in the setting of identified spinal fractures, (b) abnormal CT scan findings, and (c) pain on clinical examination without x-ray evidence of ligamentous injury. Such an approach should allow for identification of injury to the cord and soft tissue structures following trauma.
CLASSIFICATION OF SPINAL CORD INJURY
Over time, disparities in evaluation of spinal cord injury resulted in the establishment of standardized injury classification schemes to allow for better communication among specialists and researchers. Recognized classification systems include the International Standards for Neurological Classification of Spinal Cord Injury from the American Spinal Injury Association (ASIA) (23), the Fran-kel Scale (24), the modified Frankel Scale (25), Lucas and Duckers’ Neurotrauma Motor Index (26), the Yale scale (27), the National Acute Spinal Cord Injury Study scale (28), and the Sunnybrook (29) scale. Of these, the ASIA classification has emerged as the most popular classification system and will be discussed in further detail in this chapter.
The ASIA classification attempts to classify an individual’s spinal cord injury based on a standardized sensory and motor assessment. The complete assessment involves determination of the sensory and motor levels. This information is then used to identify a single neurologic level and to determine whether the patient has a complete or incomplete spinal cord injury. The ASIA classification allows for five grades of spinal cord injury (see Table 40.2). It should be noted that for grade C or D spinal cord injury, the patient must have sensory or motor function in the S4-S5 dermatome and must have voluntary anal sphincter contraction or motor function three levels below the neurologic level. These grades have proven very useful in determining prognosis, stratification of subjects within clinical trials, and communicating the severity of injury (30).
TABLE 40.2 Grading of Spinal Cord Injury Based on ASIA Classification

Grade

Description

A

Complete. No sensory or motor function is preserved

in the sacral segments.

B

Incomplete. Sensory function is preserved below the

neurologic level and includes sacral segments. No

motor function is present.

C

Incomplete. At least half of the muscle groups below

the neurologic level have muscle grade of 3 or less.

D

Incomplete. At least half of the muscle groups below

the neurologic level have a grade >3.

E

Normal sensory and motor function.

Level

Dermatome

C2

Occipital protuberance

C3

Supraclavicular fossa

C4

Top of the acromioclavicular joint

C5

Lateral side of the antecubital fossa

C6

Dorsal surface of the proximal phalanx of the thumb

C7

Dorsal surface of the proximal phalanx of the middle

finger

C8

Dorsal surface of the proximal phalanx of the little

finger

T1

Medial side of antecubital fossa

T2

Apex of the axilla

T3

Third intercostal space

T4

Fourth intercostal space

T5

Fifth intercostal space

T6

Sixth intercostal space

T7

Seventh intercostal space

T8

Eighth intercostal space (midway between T6 and T10)

T9

Ninth intercostal space

T10

Umbilicus

T11

Eleventh intercostal space

T12

Midpoint of the inguinal ligament

L1

Half the distance between T12 and L2

L2

Midanterior thigh

L3

Medial femoral condyle

L4

Medial malleolus

L5

Dorsum of foot at third metatarsophalangeal joint

S1

Lateral heel

S2

Popliteal fossa

S3

Ischial tuberosity

S4-S5

Perineal area

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Jul 5, 2016 | Posted by in NEUROSURGERY | Comments Off on Spinal Cord Injury: Assessment and Neurologic Classification

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