Vertebral Endplate Contour Abnormality
Julia Crim, MD
DIFFERENTIAL DIAGNOSIS
Common
Schmorl Node
Degenerative Endplate Changes
Limbus Vertebra
Anterior Compression Fracture
Lateral Compression Fracture
Scheuermann Disease
Osteomyelitis, Pyogenic
Sickle Cell
Less Common
Neurogenic (Charcot) Arthropathy
Osteomyelitis, Granulomatous
Cushing Disease
Osteogenesis Imperfecta
Achondroplasia
Mucopolysaccharidoses
Thanatophoric Dwarfism
Spondyloepiphyseal Dysplasia
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
May be due to trauma, developmental or congenital disorders, degenerative disease or infection
Helpful Clues for Common Diagnoses
Schmorl Node: Cup-shaped defect in endplate
Degenerative Changes: Osteophytes may elongate or form hook adjacent to endplate
Limbus Vertebra: Small separate corner portion of endplate, well-marginated
Fracture: Angular deformity of endplate, ± visible fracture line
Scheuermann Disease: Undulating endplates 4 or more levels + kyphosis, with or without discrete Schmorl nodes
Osteomyelitis: Endplate erosion, vertebral body destruction, osteopenia or osteosclerosis
Sickle Cell: Depression central portion of endplate (“Lincoln Log”)
Helpful Clues for Less Common Diagnoses
Neurogenic Arthropathy: Mimics osteomyelitis; endplate destruction and erosion, nonunited fracture fragments, heterotopic ossification
Osteomyelitis, Granulomatous: Vertebral endplate destruction and deformity, but disc spaces preserved until late; may involve multiple levels; bone fusion and kyphosis
Cushing Disease: C-shaped endplate (“fish mouth”)
Osteogenesis Imperfecta: Variable flattening and deformity due to fractures; severe osteopenia
Achondroplasia, Mucopolysaccharidoses: Anterior beak deformity
Spondyloepiphyseal Dysplasia: Vertebrae flattened but taller in center than at sides
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