Myelopathy

Myelopathy
Kevin R. Moore, MD
DIFFERENTIAL DIAGNOSIS
Common
  • Infection/Inflammation
    • Abscess, Epidural
    • Abscess, Subdural
    • Multiple Sclerosis, Spinal Cord
  • Neoplasm and Cyst
    • Syringomyelia
    • Astrocytoma, Spinal Cord
    • Ependymoma, Cellular, Spinal Cord
    • Hemangioblastoma, Spinal Cord
  • Trauma
    • Central Spinal Cord Syndrome
    • Contusion-Hematoma, Spinal Cord
    • Hematoma, Epidural-Subdural
    • Hematoma, Subdural
    • Syrinx, Post-Traumatic
  • Degenerative
    • Degenerative Disc Disease
    • Stenosis, Acquired Spinal, Cervical
    • Kyphosis
    • Spondylolisthesis
    • OPLL
    • Ossification Ligamentum Flavum
  • Intervertebral Disc Herniation
    • Intervertebral Disc Herniation, Cervical
    • Intervertebral Disc Herniation, Thoracic
    • Intervertebral Disc Herniation, Traumatic
Less Common
  • Congenital
    • Mucopolysaccharidoses
    • Stenosis, Congenital Spinal
    • Scoliosis and Kyphosis, Congenital
  • Infection/Inflammation
    • ADEM, Spinal Cord
    • Viral Myelitis
  • Neoplasm and Cyst
    • Osteochondroma
    • Pathologic Vertebral Fracture
    • Arachnoid Cyst
  • Vascular
    • Infarction, Spinal Cord
    • Type I DAVF
    • Type IV AVF
Rare but Important
  • Congenital
    • Spondyloepiphyseal Dysplasia
    • Dermoid and Epidermoid Tumors
    • Osteogenesis Imperfecta
  • Trauma
    • Spinal Cord Herniation
  • Neoplasm and Cyst
    • Neurenteric Cyst
    • Metastases, Spinal Cord
  • Vascular
    • Cavernous Malformation, Spinal Cord
    • Type II AVM
    • Type III AVM
  • Infection/Inflammation
    • Abscess/Myelitis, Spinal Cord
    • Acute Transverse Myelitis, Idiopathic
    • Secondary Acute Transverse Myelitis
    • Vitamin B12 Deficiency, Spinal Cord
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
  • Myriad etiologies requires evaluation of pertinent clinical and laboratory information to narrow differential list
Helpful Clues for Common Diagnoses
  • Infection/Inflammation
    • Epidural and subdural abscess ⇒ rim-enhancing extramedullary pus ± cord signal or compression
  • Neoplasm and Cyst
    • Syringomyelia ⇒ expanded spinal cord + central dilated, beaded, or sacculated cystic cavity
    • Neoplastic syrinx ⇒ look for nodularity or enhancement
  • Trauma
    • Central spinal cord syndrome ⇒ arms > legs + bladder dysfunction, variable sensory loss, high T2 cord signal
  • Degenerative
    • OPLL, OLF ⇒ look for ligamentous ossification with narrowing of central spinal canal
  • Intervertebral Disc Herniation
    • Use conventional diagnostic criteria
Helpful Clues for Less Common Diagnoses
  • Congenital
    • Mucopolysaccharidoses ⇒ ± dens hypoplasia, CVJ stenosis, thickened dura at foramen magnum, platyspondyly, anterior beaking, thoracolumbar gibbus deformity
    • Congenital spinal stenosis ⇒ reduced AP canal diameter secondary to short, squat pedicles and laterally directed laminae
  • Infection/Inflammation
    • ADEM, spinal cord ⇒ multifocal lesions (MS mimic) with minimal mass effect, vasogenic edema
    • Viral myelitis ⇒ swollen, edematous cord with segmental contiguous T2 signal abnormality
  • Neoplasm and Cyst
    • Osteochondroma ⇒ sessile or pedunculated osseous “cauliflower” lesion, marrow contiguous with parent vertebra
    • Arachnoid cyst ⇒ nonenhancing extramedullary loculated CSF intensity collection displacing cord or nerve roots
  • Vascular
    • Spinal cord infarction ⇒ central T2 hyperintensity more common than wedge-shaped injury in anterior 2/3 spinal cord
Helpful Clues for Rare Diagnoses
Aug 7, 2016 | Posted by in NEUROLOGY | Comments Off on Myelopathy

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