Myelopathy
Kevin R. Moore, MD
DIFFERENTIAL DIAGNOSIS
Common
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Infection/Inflammation
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Abscess, Epidural
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Abscess, Subdural
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Multiple Sclerosis, Spinal Cord
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Neoplasm and Cyst
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Syringomyelia
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Astrocytoma, Spinal Cord
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Ependymoma, Cellular, Spinal Cord
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Hemangioblastoma, Spinal Cord
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Trauma
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Central Spinal Cord Syndrome
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Contusion-Hematoma, Spinal Cord
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Hematoma, Epidural-Subdural
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Hematoma, Subdural
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Syrinx, Post-Traumatic
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Degenerative
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Degenerative Disc Disease
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Stenosis, Acquired Spinal, Cervical
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Kyphosis
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Spondylolisthesis
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OPLL
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Ossification Ligamentum Flavum
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Intervertebral Disc Herniation
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Intervertebral Disc Herniation, Cervical
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Intervertebral Disc Herniation, Thoracic
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Intervertebral Disc Herniation, Traumatic
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Less Common
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Congenital
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Mucopolysaccharidoses
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Stenosis, Congenital Spinal
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Scoliosis and Kyphosis, Congenital
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Infection/Inflammation
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ADEM, Spinal Cord
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Viral Myelitis
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Neoplasm and Cyst
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Osteochondroma
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Pathologic Vertebral Fracture
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Arachnoid Cyst
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Vascular
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Infarction, Spinal Cord
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Type I DAVF
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Type IV AVF
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Rare but Important
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Congenital
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Spondyloepiphyseal Dysplasia
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Dermoid and Epidermoid Tumors
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Osteogenesis Imperfecta
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Trauma
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Spinal Cord Herniation
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Neoplasm and Cyst
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Neurenteric Cyst
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Metastases, Spinal Cord
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Vascular
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Cavernous Malformation, Spinal Cord
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Type II AVM
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Type III AVM
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Infection/Inflammation
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Abscess/Myelitis, Spinal Cord
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Acute Transverse Myelitis, Idiopathic
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Secondary Acute Transverse Myelitis
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Vitamin B12 Deficiency, Spinal Cord
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ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
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Myriad etiologies requires evaluation of pertinent clinical and laboratory information to narrow differential list
Helpful Clues for Common Diagnoses
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Infection/Inflammation
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Epidural and subdural abscess ⇒ rim-enhancing extramedullary pus ± cord signal or compression
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Neoplasm and Cyst
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Syringomyelia ⇒ expanded spinal cord + central dilated, beaded, or sacculated cystic cavity
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Neoplastic syrinx ⇒ look for nodularity or enhancement
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Trauma
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Central spinal cord syndrome ⇒ arms > legs + bladder dysfunction, variable sensory loss, high T2 cord signal
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Degenerative
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OPLL, OLF ⇒ look for ligamentous ossification with narrowing of central spinal canal
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Intervertebral Disc Herniation
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Use conventional diagnostic criteria
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Helpful Clues for Less Common Diagnoses
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Congenital
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Mucopolysaccharidoses ⇒ ± dens hypoplasia, CVJ stenosis, thickened dura at foramen magnum, platyspondyly, anterior beaking, thoracolumbar gibbus deformity
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Congenital spinal stenosis ⇒ reduced AP canal diameter secondary to short, squat pedicles and laterally directed laminae
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Infection/Inflammation
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ADEM, spinal cord ⇒ multifocal lesions (MS mimic) with minimal mass effect, vasogenic edema
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Viral myelitis ⇒ swollen, edematous cord with segmental contiguous T2 signal abnormality
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Neoplasm and Cyst
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Osteochondroma ⇒ sessile or pedunculated osseous “cauliflower” lesion, marrow contiguous with parent vertebra
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Arachnoid cyst ⇒ nonenhancing extramedullary loculated CSF intensity collection displacing cord or nerve roots
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Vascular
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Spinal cord infarction ⇒ central T2 hyperintensity more common than wedge-shaped injury in anterior 2/3 spinal cord
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Helpful Clues for Rare Diagnoses
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Congenital
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Dermoid and epidermoid tumors ⇒ CSF isodense/isointense lumbosacral or cauda equina mass
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Osteogenesis imperfecta ⇒ severe osteopenia & multiple fractures
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Trauma
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Spinal cord herniation ⇒ herniation of spinal cord through defect in dura of ventral canal with expansion of dorsal subarachnoid space
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Neoplasm and Cyst
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Neurenteric cyst ⇒ intraspinal cyst lined by enteric mucosa + vertebral segmentation abnormalities
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Spinal cord metastasis ⇒ focal, enhancing cord lesion(s) + extensive edema
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Vascular
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Cavernous malformation ⇒ locules of blood with fluid-fluid levels surrounded by T2 hypointense rim
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Type II AVM ⇒ intramedullary glomus type AVM (similar to brain AVM), nidus may extend to dorsal subpial surface
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Type III AVM ⇒ juvenile-type AVM (intramedullary, extramedullary), nidus may have extramedullary and extraspinal extension
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