Soft Tissue Calcification, Paraspinal
Julia Crim, MD
DIFFERENTIAL DIAGNOSIS
Common
Heterotopic Ossification
DISH
Spinal Muscle Injury, Traumatic
Post-Operative Change, Normal
Neurogenic (Charcot) Arthropathy
Calcification
Calcific Tendinitis, Longus Coli
Osteomyelitis, Granulomatous
Less Common
Heterotopic Ossification
Spondyloarthropathy, Seronegative
Osteosarcoma
Calcification
Schwannoma
Polymyositis/Dermatomyositis
Spondyloarthropathy, Hemodialysis
Juvenile Idiopathic Arthritis
Rare but Important
Fibrodysplasia Ossificans Progressiva (FOP)
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
Heterotopic ossification: General term meaning bone forming outside normal sites
Myositis ossificans: Heterotopic ossification forming in muscles
Causes: Trauma, surgery; paraplegia
Helpful Clues for Common Diagnoses
Heterotopic Ossification
Over time, forms cortex and internal trabeculae
In osteosarcoma, structure lacking
DISH, seronegative spondyloarthropathy: Ossification of paraspinous ligaments follows ligament contour
Charcot arthropathy: Combination of florid periosteal new bone and small bone fragments in soft tissues
Usually more exuberant and disorganized than post-traumatic heterotopic ossification
“5 Ds” of Charcot joint: Preserved or increased density, bone debris, destruction, joint distention, joint dislocation
Calcification
Calcific tendinopathy of longus coli: Linear calcification associated with longus coli muscle edema, often fluid collection
Hydroxyapatite, gout, or scleroderma: Amorphous or globular
Calcium pyrophosphate deposition disease: Linear
Granulomatous infection: Irregularly shaped, associated with abscess
Polymyositis: Fine, reticular pattern along fascial planes
Helpful Clues for Less Common Diagnoses
Juvenile Idiopathic Arthritis
Periosteal new bone or ligament ossification
Image Gallery
Coronal bone CT shows post-traumatic ossification in paraspinous fat. Mature bone architecture distinguishes it from osteosarcoma.
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