(Modified from Spinner RJ, Dyck PJB, et al. Targeted Fascicular Biopsy: A Surgical Perspective. By permission of Mayo Foundation of Medical Education and Research. All rights reserved.)
Figure 3-2 Representative targeted fascicular biopsies. A, Single fascicle obtained from tibial division of sciatic nerve in buttock region shows nodularity. Histology showed onion bulbs characteristic of chronic inflammatory demyelinating polyneuropathy. B, Single fascicle obtained from the tibial nerve in distal thigh showed sheets of amyloidosis. C, Single fascicle obtained from sciatic nerve in buttock showed “blue” infiltrate and proved to be prostate adenocarcinoma.
Hemostasis is achieved with a bipolar cautery. The wound is irrigated copiously and closed in anatomic layers. Subcuticular sutures are placed with adhesive skin closures (Steri-Strips, St. Paul, Minnesota). The procedures take between 45 and 90 minutes, depending on the site of the biopsy and need for intraoperative pathology interpretation.
Patients are discharged from the hospital the same day or observed after a 23-hour observation period and re-evaluated together with the neurologist at several weeks postoperatively, when the pathology is finalized. At that time, recommendations for target-specific therapy are discussed with the patient.