Quantitative Genetics
Quantitative Genetics Anita Thapar Peter McGuffin Patterns of inheritance Our understanding of how traits and disorders are passed from one generation to the next began with the work carried out…
Psychoneuroimmunology
Psychoneuroimmunology Robert Dantzer Keith W. Kelley Introduction Mind-body literature, in the form of magazines and self-help books on stress and healing, is full of definitive claims for the existence of…
Neuronal Networks, Epilepsy, and Other Brain Dysfunctions
Neuronal Networks, Epilepsy, and Other Brain Dysfunctions John G. R. Jefferys Introduction The dynamics of highly interconnected networks of neurones are fundamental to both normal and pathological functioning of the…
Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging E. T. Bullmore J. Suckling Introduction Functional magnetic resonance imaging (fMRI) is a relatively new technique for measuring changes in cerebral blood flow. The first fMRI…
Structural Magnetic Resonance Imaging
Structural Magnetic Resonance Imaging J. Suckling E. T. Bullmore Introduction Magnetic resonance imaging (MRI) is a versatile and evolving technology for visualizing the structure, function, and metabolism of the living…
Functional Positron Emission Tomography in Psychiatry
Functional Positron Emission Tomography in Psychiatry P. M. Grasby Introduction Positron emission tomography (PET) and single-photon emission tomography (SPET) are powerful tools for investigating the pathophysiology of psychiatric illnesses and…
Neuropathology
Neuropathology Peter Falkai Bernhard Bogerts Introduction The traditional domains of neuropathology are well-defined organic brain diseases with an obvious pathology, such as tumours, infections, vascular diseases, trauma, or toxic and…
Neurotransmitters and Signalling
Neurotransmitters and Signalling Trevor Sharp By the end of the 19th century it was recognized that signalling from one neurone to the next occurs at specialized contacts – Sherrington coined…
Neuroendocrinology
Neuroendocrinology Charles B. Nemeroff Gretchen N. Neigh Definitions and principles In the late 1950s, a controversy arose in endocrinology and neuroscience concerning whether neurones are capable of manufacturing and secreting…
Neurodevelopment
Neurodevelopment Karl Zilles Neural induction The central nervous system originates from the midline region of the embryo as a specialized area of ectoderm, the neuroectoderm, or neural plate. FGF (fibroblast…
