Basic Organization of Territories That Become Sequentially Involved After Initial Involvement of Brainstem Nuclei with Diffuse Projections

Sep 24, 2016 by in NEUROLOGY Comments Off on Basic Organization of Territories That Become Sequentially Involved After Initial Involvement of Brainstem Nuclei with Diffuse Projections

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   6.1 The Cerebral Cortex The cerebral cortex is the overarching superordinate structure of the…

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Alzheimer-Associated Pathology in the Extracellular Space

Sep 24, 2016 by in NEUROLOGY Comments Off on Alzheimer-Associated Pathology in the Extracellular Space

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   8.1 The Amyloid Precursor Protein and the Abnormal Protein Aβ A clear indicator for…

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The Pattern of Lesions During the Transition to the Symptomatic Phase and in Fully Developed Alzheimer’s Disease

Sep 24, 2016 by in NEUROLOGY Comments Off on The Pattern of Lesions During the Transition to the Symptomatic Phase and in Fully Developed Alzheimer’s Disease

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   9.1 NFT Stage III: Progression into the Basal Temporal Neocortex, Including Portions of the…

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The Pattern of Cortical Lesions in Preclinical Stages

Sep 24, 2016 by in NEUROLOGY Comments Off on The Pattern of Cortical Lesions in Preclinical Stages

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   7.1 Stages 1a and 1b: Development of Inclusions in Axons and of Pretangle Material…

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Introduction

Sep 24, 2016 by in NEUROLOGY Comments Off on Introduction

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   2.1 Sporadic AD Is a Proteinopathy Linked to the Development of Intraneuronal Inclusions of…

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Early Presymptomatic Stages

Sep 24, 2016 by in NEUROLOGY Comments Off on Early Presymptomatic Stages

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   5.1 Stage a: The Appearance of Abnormal Tau in Axons of Coeruleus Projection Neurons…

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Technical Addendum

Sep 24, 2016 by in NEUROLOGY Comments Off on Technical Addendum

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   Brains obtained at autopsy—following precautions for handling tissue of prion diseases—are fixed by immersion…

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Microtubules and the Protein Tau

Sep 24, 2016 by in NEUROLOGY Comments Off on Microtubules and the Protein Tau

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   The protein tau is central to the pathological process underlying sporadic AD. It is…

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Final Considerations

Sep 24, 2016 by in NEUROLOGY Comments Off on Final Considerations

and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany   The present exposition of the AD-related pathological process rests upon some basic assumptions: (1)…

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