General Approach and Differential Diagnosis

Oct 22, 2018 by in NEUROLOGY Comments Off on General Approach and Differential Diagnosis

General Approach and Differential Diagnosis Clinical and Neuroimaging Variables The interpretation of routine H&E-stained sections and immunohistochemistry from CNS lesions can be difficult and risky when performed outside of the…

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Intraoperative Consultation

Oct 22, 2018 by in NEUROLOGY Comments Off on Intraoperative Consultation

Intraoperative Consultation Intraoperative neuropathology consultation can be a significant source of anxiety to the general surgical pathologist who covers only an occasional neurosurgical specimen, particularly early in one’s career. It…

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Metastases

Oct 22, 2018 by in NEUROLOGY Comments Off on Metastases

Metastases Clinical Context Metastases are the most common tumors in the central nervous system (CNS), accounting for more lesions than all primary tumors combined (1), and affecting just over half…

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Hematolymphoid Neoplasms

Oct 22, 2018 by in NEUROLOGY Comments Off on Hematolymphoid Neoplasms

Hematolymphoid Neoplasms Primary CNS Lymphoma Although primary central nervous system lymphoma (PCNSL) technically includes any lymphocytic neoplasms restricted to the central nervous system (CNS), the term is usually understood to…

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Germ Cell Tumors

Oct 22, 2018 by in NEUROLOGY Comments Off on Germ Cell Tumors

Germ Cell Tumors Clinical Context Extragonadal germ cell neoplasms are uncommon in the central nervous system (CNS), accounting for less than 1% of all primary CNS tumors in the United…

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Vascular Malformations and Other Select Vascular Lesions

Oct 22, 2018 by in NEUROLOGY Comments Off on Vascular Malformations and Other Select Vascular Lesions

Vascular Malformations and Other Select Vascular Lesions Arteriovenous Malformation Clinical Context Arteriovenous malformations (AVMs) are congenital vascular abnormalities that typically present between the ages of 20 and 40 years with…

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Cranial and Spinal Nerve Sheath Tumors

Oct 22, 2018 by in NEUROLOGY Comments Off on Cranial and Spinal Nerve Sheath Tumors

Cranial and Spinal Nerve Sheath Tumors Schwannoma Clinical Context A large number of neurosurgical specimens originate outside of the central nervous system (CNS) proper from the perineural cells of the…

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Tumors of the Pineal Region

Oct 22, 2018 by in NEUROLOGY Comments Off on Tumors of the Pineal Region

Tumors of the Pineal Region Pineocytoma (WHO Grade I), Pineal Parenchymal Tumor of Intermediate Differentiation (WHO Grade II to III), and Pineoblastoma (WHO Grade IV) Pineal parenchymal tumors occupy a…

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Choroid Plexus Tumors

Oct 22, 2018 by in NEUROLOGY Comments Off on Choroid Plexus Tumors

Choroid Plexus Tumors Choroid Plexus Papilloma (WHO Grade I), Atypical Choroid Plexus Papilloma (WHO Grade II), and Choroid Plexus Carcinoma (WHO Grade III) Clinical Context Altogether, tumors of the choroid…

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