A Multiscale “Working Brain” Model

Dec 17, 2016 by in PSYCHIATRY Comments Off on A Multiscale “Working Brain” Model

Fig. 5.1 Schematic of “working brain” model, showing structures involved in corticothalamic generation of EEGs and the brainstem-hypothalamus ascending arousal system (see section “Arousal State Modeling” for abbreviations), with some…

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Discovery and Validation of Biomarkers Based on Computational Models of Normal and Pathological Hippocampal Rhythms

Dec 17, 2016 by in PSYCHIATRY Comments Off on Discovery and Validation of Biomarkers Based on Computational Models of Normal and Pathological Hippocampal Rhythms

accumulation. This can help elucidate a mechanism of age-dependent theta oscillation changes in AD mouse models, reflecting changes in synchronous synaptic activity that could mediate oscillation-dependent memory deficiencies and serve…

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Computational Modeling of Neuronal Dysfunction at Molecular Level Validates the Role of Single Neurons in Circuit Functions in Cerebellum Granular Layer

Dec 17, 2016 by in PSYCHIATRY Comments Off on Computational Modeling of Neuronal Dysfunction at Molecular Level Validates the Role of Single Neurons in Circuit Functions in Cerebellum Granular Layer

Fig. 8.1 Schematic representation of cerebellar circuits. At the sub-cortical levels, afferent fibers carrying sensory information activate the deep cerebellar nuclei and inferior olive cells. In the cerebellar cortex, there…

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Introduction

Dec 17, 2016 by in PSYCHIATRY Comments Off on Introduction

(1.1) Where V represents the membrane potential, C represents the membrane capacitance, g m —the conductance of a particular ion-channel, V m is this ion’s reversal potential and I(t) represents…

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