Pseudotype envelope Tropism and other features References Amphotropic MLV Efficient transduction of hematopoietic progenitor cells, T lymphocytes Reviewed in [60] Aura virus Transduction of monocyte derived dendritic cells (DCs), useful…
Fig. 1 Configuration of the stereotactic frame for injection of rat dorsal root ganglia. (a) First the electrode holder is placed in inverted orientation. (b) The manipulator is swiveled 180°…
Target gene Injection region Vector Experimental model Functional outcome References GAD Substantia nigra Engineered cells overexpressing GAD65 Kindling Increased seizure threshold Thompson et al. [66] Substantia nigra Engineered cells overexpressing…
Serotype Natural host/origin Optimal organ/tissue/cell type transduced CNS area transduced Receptor Coreceptor Blood–brain barrier penetration Disease targets AAV1 Monkey Muscle [39], Liver [110], CNS [32, 42] SNpc, SNpr, midbrain, hippocampus…
Fig. 1 (a) Nine copies of Epo HRE consensus sequence. The HIF-1 binding sites are underlined. (b) Schematic drawing of H9LacZ and H9VEGF. Nine copies of Epo HRE (9HRE) were…
Volume Reagent Final concentration Complete DMEM media 500 mL DMEM (Invitrogen #12430-062) 50 mL Fetal bovine serum (Thermo HyClone #SH30406.02) 9 % 5 mL Non-essential amino acids (100×, Invitrogen, #11140050)…
Author (reference) Animal System Age/injection site Proliferation (RTK/KRAS/PI3K) Apoptosis (p53/ARF) Cell cycle (Rb/INK4) Best combined penetrance Holland et al. 2000 [13] Mice RCAS Neonatal/R frontal AKT, KRAS 26 % Dai…
Fig. 1 Behavioral tests for the functional recovery after rubrospinal tract transection. (a) Photo showing the symmetrical use of both forelimbs of the rat during vertical exploration of the cylinder…
Stroke type Percentage (% of each category) Ischemic 85 Carotid artery circulation 55 Vertebral/basilar artery circulation 12 Lacune 31 Other (vasculopathy, coagulopathy, sickle cell, hyperviscosity, vasculitis) 2 Hemorrhagic 14 Hypertensive…
Frontal lobe Wechsler memory scale Milan sorting test Porteus maze test Parietal lobe Wechsler block design Benton figure copying test Temporal lobe Halstead–Reitan battery (parts) Milner’s maze learning task Intelligence…
