html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 30 Lessons and challenges of trials for cognitive and behavioral complications of Parkinson’s disease Daniel Weintraub and Lama M. Chahine Introduction There has been increasing…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 28 Controversy: ablative surgery vs deep-brain stimulation in the management of Parkinson’s disease Gian D. Pal and Leo Verhagen Metman Introduction The concept of surgically…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 27 Controversy: globus pallidus internus versus subthalamic nucleus deep-brain stimulation in the management of Parkinson’s disease Sarah K. Bourne, Sean J. Nagel and Darlene A….
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 26 Lessons learned: symptomatic trials in early Parkinson’s disease Ramon Lugo-Sanchez and Néstor Gálvez-Jiménez Introduction This chapter will try to explain the concept of “early”…
Figure 25.1 Schematic representation of the theoretical effect of neuroprotective, symptomatic, or mixed neuroprotective and symptomatic treatments compared with placebo in different study designs. The x-axis represents time and the…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 23 Functional imaging markers as outcome measures in clinical trials for Parkinson’s disease Ryan R. Walsh Introduction There is currently no validated functional imaging marker…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 22 Rating scales and clinical outcome measures in the evaluation of patients with Parkinson’s disease Pablo Martinez-Martin and Carmen Rodríguez-Blázquez Introduction In recent years, the…
Figure 20.1 A sagittal slice through the thalamus taken 14.5 mm from the midline. The ventral intermediate nucleus, shown in red, is the target for tremor therapy in deep-brain stimulation…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 21 Emerging targets and other stimulation-related procedures in the management of Parkinson’s disease Tiago A. Mestre and Elena Moro Introduction Since the first report from…
Figure 18.1 Microelectrode mapping of the globus pallidus. Characteristic firing patterns seen in the striatum (1), globus pallidus externus (GPe) (2), border cells (3) and globus pallidus internus (GPi) (4)….
