Treatment of Brain Tumors: Electrochemotherapy

Mar 17, 2017 by in NEUROLOGY Comments Off on Treatment of Brain Tumors: Electrochemotherapy

Fig. 22.1 Electroporation (a) By application of brief electric pulses it is possible to transiently permeabilise the cell membrane (electroporation). This allows free passage of molecules to the cell cytosol…

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The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance

Mar 17, 2017 by in NEUROLOGY Comments Off on The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance

Fig. 24.1 General schematic of cellular GSH biosynthesis, utilization, export, and salvage. Glutathione (GSH) biosynthesis requires two ATP-dependent reactions: the glutamate cysteine ligase (GCL)-mediated formation of γ-glutamylcysteine (γGC) from glutamate…

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