Fig. 1 Gene ontology (cellular components) of the 66 ASD-associated genes. The insert details the neuronal components Fig. 2 Gene ontology (molecular processes) of the 66 ASD-associated genes Fig. 3…
Neurodevelopmental deficits typical of autism in humans Triad grouping Nonhuman primates Behavioral deficits resulting from trauma, social isolation, and poor living conditions Behavioral deficits in captivity Behavioral deficits in wild…
Fig. 1 Schematic representation of the TSC1 and TSC2 proteins, showing phosphorylation sites and important structural and functional features [15]. Numbers are according to the human amino acid sequences. 3…
Fig. 1 Induced pluripotent stem cells strategy to orient cell development towards differentiated neurons Taking fibroblasts in patients with a genetic disease, transforming the adult cells into iPSCs and reprogramming…
Fig. 1 The figure summarizes neurobiological processes that have been found to be abnormal in mouse models of tuberous sclerosis and that could contribute to the neuropsychiatric manifestations associated with…
Fig. 1 Schematic representation of the Mecp2 gene and localization of the modifications made to engineer Mecp2-deficient mouse models. See text for details Hundreds of MECP2 mutations are known in…
Animal models 5-HT-related abnormalities Region References Developmental hyperserotonemia model (DHS) Increase Whole (nonspecific 5-HT receptors agonist) [37, 38, 113] VPA treatment for embryo Decrease/Increase 5-HT Abnormal migration of 5-HT neurons…
© Springer Science+Business Media New York 2015Pierre L. Roubertoux (ed.)Organism Models of Autism Spectrum DisordersNeuromethods10010.1007/978-1-4939-2250-5_12 12. Zebrafish Social Behavior Testing in Developmental Brain Disorders Christine Buske1 (1) Papers/Springer SBM, 236 Gray’s Inn Road – Floor…
Fig. 1 Chromatin structure is a dynamic structure that contributes to gene regulation. Heterochromatin is highly compacted and usually associated with silenced genes while euchromatin corresponds to actively transcribed genes….
© Springer Science+Business Media New York 2015Pierre L. Roubertoux (ed.)Organism Models of Autism Spectrum DisordersNeuromethods10010.1007/978-1-4939-2250-5_10 10. Communication and Language in Animals Gene S. Fisch1 (1) Department of Epidemiology & Health Promotion, NYU Colleges of Dentistry &…
