Fig. 15.1 Reduced respiratory response to hypercapnia The indices of VRH of the DLB patients, AD patients, and controls were 0.156 ± 0.10, 0.431 ± 0.04, and 0.466 ± 0.09, respectively (Fig. 15.2). VRH in DLB patients…
Fig. 10.1 (a–d) MRI findings of characteristic AD and DLB cases. (a) Probable AD case. Medial temporal lobe atrophy (MTA) is prominently evident bilaterally. (b) Probable DLB case. MTA is…
Fig. 11.1 Nigrostriatal dopaminergic synapse and targets of PET and SPECT ligands. Tyrosine is converted to L-DOPA by tyrosine hydroxylase. L-DOPA is then converted to dopamine, which is gathered into…
Fig. 1.1 Typical brain stem-type Lewy body (upper) and cortical Lewy body (lower) and the distribution of Lewy bodies in our first case Fig. 1.2 Alpha-synuclein-immunostained Lewy bodies in the…
Diffuse Lewy body disease (DLBD) Kosaka et al. [1], Dickson et al. [2], Lennox et al. [3] Lewy body dementia (LBD) Gibb et al. [4] Lewy body variant of Alzheimer’s…
Fig. 6.1 Differentiation between DLB and AD DLB by using neuropsychological tests. (a) ADAS word recall score and WAIS-R blocks design score. (b) Total MMSE score and MMSE calculation/attention score…
Rest tremor Freezing Rigidity Freezing Bradykinesia Festination Reptile stare Abnormal posture Masked face Camptocormia Small voice Pisa syndrome Dysphagia Head drop Bradykinesia Loss of automatic acts Micrographia Drooling Shuffling gait…
© Springer Japan KK 2017Kenji Kosaka (ed.)Dementia with Lewy Bodies10.1007/978-4-431-55948-1_3 3. Cholinergic Pathology in Dementia with Lewy Bodies John-Paul Taylor1 , Daniel Collerton1, Fiona LeBeau1 and Elaine Perry1 (1) Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL,…
© Springer Japan KK 2017Kenji Kosaka (ed.)Dementia with Lewy Bodies10.1007/978-4-431-55948-1_7 7. Behavioral and Psychological Symptoms of Dementia Yuta Manabe1, 2, 3 and Kenji Kosaka3, 4 (1) Dementia Diagnostic Center, Yokohama Shintoshi Neurosurgery Hospital, 433, Eda-chou, Aoba-ku,…
Study No. in study Age (years) No. with dementia No. of DLB DLB/over 65 years, % (95 %CI) DLB/all dementia, % (95 %CI) Yamada (2001) 3715 65 142 4 0.11 (0.03–0.28) 0.28…
