Abstract While the evidence for many applications of vagus nerve stimulation (VNS) is preliminary, new noninvasive VNS devices have recently been developed and represent significant advancements in VNS therapy. A…
Abstract Muscle and fat cells, unlike nerve and immune cells, require insulin for the efficient uptake of circulating glucose. Prolonged inflammation and the expression of key cytokines have the effect…
Abstract Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) cause significant morbidity and mortality despite significant advances in treatment. A large body of preclinical work has shown that vagus nerve…
Abstract Bladder pain syndrome/interstitial cystitis (BPS/IC) is a severely debilitating, chronic disorder characterized by pain perceived to arise from the bladder, exacerbated by bladder filling, and associated with urinary urgency…
Abstract While restoration of inspiratory muscle function to restore breathing in ventilator-dependent spinal cord injured (SCI) subjects is an important clinical modality, restoration of expiratory muscle function may be even…
Abstract The “inflammatory reflex” is an important neural-immune mechanism that can be activated by electrical vagus nerve stimulation (VNS) to drive pleiotropic antiinflammatory effects in the periphery. It has therefore…
Abstract The urogenital system has two major subdivisions: (1) the urinary tract, which is responsible for the production, storage, and elimination of urine, and (2) the genital tract, which is…
Abstract Many neuromodulation devices used to treat disease and injury are “open-loop” in nature and lack sensing and the algorithms required to automatically adjust or provide stimulation based on a…
Abstract The mammalian nervous system is essential to protecting the host against injury. Arguably the most important priority after traumatic injury is hemorrhage control. Herein we describe how the central…
Abstract The heart is controlled by dynamic interactions within the cardiac autonomic nervous system (ANS). This interaction occurs between intrathoracic extracardiac and intrinsic cardiac ganglia as well as between peripheral…
