Bioethics and the Family
“Medical technology has effectively created a twilight zone of suspended animation where death commences while life, in some form, continues.” —Justice William Brennan, 1990, regarding the case of Nancy Cruzan…
Pain, Sedation, and Delirium in Critical Illness
Introduction Patient comfort in an intensive care unit (ICU), from both a mental and physical health perspective, is of utmost importance for patient safety and recovery. Proper management of analgesia…
Outcome Scales and Neuropsychological Outcome
Introduction The incidence of mortality and illness-related complications has long been documented in the medical literature. More recently, the measurement of outcomes has gained increasing attention because advanced medical procedures,…
Recurrent Glioblastoma
Given the aggressive nature of glioblastoma, it is nearly a certainty that all patients will need to be evaluated for potential treatment of recurrent disease. There is currently no definitive…
Lessons Learned: Clinical Trials and Other Interventions for Glioblastoma
Glioblastoma (GBM) remains the most common primary malignant brain tumor in adults and accounts for 16% of all primary brain tumors and for 45% of malignant primary brain tumors. Despite…
National and Global Economic Impact of Glioblastoma
Introduction The cost of cancer treatment has progressively increased over the past decade as newer chemotherapy and immunotherapy agents have been established. Glioblastoma, in particular, has a significant cost in…
Tumor-Treating Electric Fields for Glioblastoma
Acknowledgments The authors acknowledge and thank Kisa Zhang for her artwork in Fig. 17.1 . Historical context of electric field treatment The application of physical energy from various parts of the…
Health-related Quality of Life and Neurocognitive Functioning After Glioblastoma Treatment
Introduction With a median survival of 12 to 14 months, the prognosis of patients with glioblastoma multiforme (GBM) remains poor. Treatment is therefore not only designed to prolong survival but also…
Socioeconomics and Survival
Introduction Accounting for 52% of all primary brain tumors, glioblastoma is the most common and most aggressive. Glioblastomas account for 20% of all intracranial tumors. Disparities in risk factors, incidence,…
Brain Plasticity and Reorganization Before, During, and After Glioma Resection
Introduction The traditional principle in neuro-oncology is to study the tumor first, with little consideration regarding the host; that is, the brain. Nevertheless, to define the optimal therapeutic management for…
