Abstract This chapter introduces the reader to the role organized neurosurgery has played in the past 10–15 years in its efforts to advance patient safety in neurosurgical practice. We discuss…
Abstract Recent years have seen a steady increase in the attention paid to quality and safety with regard to hospitalized patients. The topic has transitioned from being a lofty ideal…
Abstract Currently, 17 transcription factors are known to form the Krüppel-like factor (KLF) family. All transcription factors of the KLF family resemble the members of the specificity protein (Sp) family;…
Abstract The small non-coding RNAs are called microRNAs or miRNAs that play key roles in mRNA silencing as well as in post-transcriptional regulation of gene expression in eukaryotic cells. The…
Abstract Neuroblastoma is the most common malignancy in infancy and the most common extracranial solid tumor in the pediatric age group. There is only approximately 30%–40% long-term survival rates among…
Abstract This chapter introduces the molecular targeted therapies and immunotherapies currently in use to treat neuroblastoma, which is the most common extracranial solid tumor in children. It presents a clinical…
Abstract Antiangiogenic strategies are currently in use for the treatment of cancer, and the inhibition of angiogenesis could represent a powerful adjunct to traditional therapy of malignant tumors. Over the…
Abstract The management of neuroblastoma requires a multidisciplinary approach led by the pediatric surgeon. Surgical biopsy and resection are essential to characterize the tumor, stratify patient risk, and guide the…
Abstract More than 50% of patients with high-risk neuroblastoma will relapse despite intensive multi-modal therapy. Management of these patients is challenging, given disease heterogeneity, resistance, and organ toxicity. Recent advances…
Abstract In the cell, autophagy is the major regulatory catabolic mechanism responsible for the maintenance of cellular homeostasis. It is active at a basal level in all cell types, and…
