Abstract Bacterial meningitis occurs in approximately 0.4 neonates per 1000 live births. Virtually all organisms that cause neonatal infection or sepsis can result in central nervous disease with severe consequences…
Abstract The past decade has witnessed a major transformation in our understanding of epilepsies presenting in the neonatal period. Old broad umbrella syndromes, such as Ohtahara syndrome and early myoclonic…
Abstract Glucose homeostasis is the foundation of energy supply and maintenance during the transition period of fetal to newborn life. Despite this important position, our understanding of its vital role…
Abstract Stroke is a common neurologic disorder in the neonatal period that results in significant morbidity. This chapter discusses the classification, epidemiology, and clinical presentation of arterial, venous, and hemorrhagic…
Abstract The development of hydrocephalus substantially worsens the neurodevelopmental prognosis after intraventricular hemorrhage (IVH). Frequent standardized measurements of ventricular dimensions and daily head circumference are essential after grade III and…
Abstract Seizures in newborns are the most frequent manifestation of an acute neurologic dysfunction, but sometimes they can be the early onset of an epileptic encephalopathy, mainly of genetic origin….
Abstract Hypoxic-ischemic encephalopathy (HIE) is an infrequent event with a potentially neurologically devastating outcome. Severe and prolonged interruption of placental blood flow will ultimately lead to asphyxia, the biochemical process…
Abstract Perinatal hypoxic-ischemic encephalopathy is a neurological condition which is etiologically linked to death and neurodevelopmental impairment later in childhood. Until clinical trials of therapeutic hypothermia were conducted, treatment was…
Abstract Despite advances in our understanding of developmental hemodynamics and our ability to better monitor the cardiovascular status in neonates, the definition of the “normal” gestational age– and postnatal age–dependent…
Abstract This chapter focuses on a brief review of the pathogenesis of periventricular intraventricular hemorrhage as well as white matter injury. Various approaches or strategies for the prevention, diagnosis, and…
