Fig. 34.1 Sural nerve biopsy. Plastic toluidine blue stained semi-thin sections at a lower magnification (a) and a higher magnification (b) show a minimally reduced density of myelinated fibers with…
Fig. 33.1 Amyloid neuropathy. (a) Toluidine blue stained resin embedded plastic section of the biopsied nerve shows an end stage nerve with severe depletion of myelinated axons. (b) Congo red…
Fig. 32.1 Lupus vasculitidies. (a), H&E stained cryostat section of sural nerve shows one epineurial vessel with scant perivascular inflammation (arrow). (b), Toluidine blue stained resin embedded plastic section of…
Fig. 30.1 Acid maltase deficiency. (a) H&E shows a vacuolar myopathy. (b) ATPase at pH 9.4 shows that the myofibers that contain vacuoles are predominantly type 2. There is also type…
Fig. 28.1 Muscle biopsy findings of the left quadriceps muscle. (a), H&E shows excessive variation in fiber diameter without increased internal nuclei, muscle fiber necrosis or regeneration. Nemaline rods and…
Fig. 27.1 Muscle biopsy findings of the left quadriceps. (a) H&E showing excessive variation of fiber diameters and mild increase in endomysial connective tissue. ATPase histochemistry (not shown) demonstrates that…
Fig. 26.1 Muscle biopsy findings of the right quadriceps muscle. (a) H&E showing excessive variation in fiber diameter, and increased numbers of fibers with centrally placed nuclei. (b) NADH-TR histochemistry…
Fig. 25.1 Muscle pathology in merosin deficiency. (a) H&E stained cryostat section shows an end stage muscle with few remaining fibers. Immunostaining shows intact alpha-dystroglycan (b) and dystrophin (c, DYS2…
Fig. 24.1 Duchenne muscular dystrophy . (a) H&E shows dystrophic changes (asterisks indicate necrotic fibers, arrow indicates myofiber with abnormal internal architecture). (b) Immunostaining for dystrophin N terminus (DYS3) shows…
Fig. 22.1 H&E stained muscle biopsy section (a) shows striking endomysial fibrosis, abundant severely atrophic fibers and pyknotic nuclear clumps, and a few hypertrophic fibers. A split fiber is also…
