Institute Country Total Stroke type Cell dose Administration Status Identifier Universidade Federal do Rio de Janeiro Brazil 20 Chronic (2–3 months) 1–5 × 108 Intra-arterial Complete (2011) [39] NCT00473057 The University of Texas…
Exogenous labeling Endogenous labeling MRI T1WI Gd, Mn T2WI SPIO MR reporter gene Nuclear imaging SPECT 111In-oxine, 99mTc-HMPAO Reporter gene PET 18F- FDG Optical imaging FI QD, organic…
Fig. 9.1 Representative findings of 123I-IMZ SEPCT. White-and-black images of the vehicle- (a) and bone marrow stromal cell (BMSC)-transplanted rats (b). In both vehicle- and BMSC-treated rats, a marked decrease…
Fig. 3.1 NSC and neurosphere method NSCs exist in at least two regions of the adult brain – the subventricular zone of the lateral ventricle and the subgranular zone of…
ID Study Sponsor (country) 1st received Condition of patients Cell source (product code) Delivery route Phase Status of trials NCT00473057 Study of Autologous Stem Cell Transplantation for Patients With Ischemic…
© Springer Japan KK 2017Kiyohiro Houkin, Koji Abe and Satoshi Kuroda (eds.)Cell Therapy Against Cerebral Stroke10.1007/978-4-431-56059-3_7 7. Role of Biomaterials as Scaffolding in Cell Therapy for Stroke Toshiya Osanai1 (1) Department of Neurosurgery, Hokkaido University Graduate School…
Fig. 4.1 Summary of induction of iPSCs, iNSCs, and iNCs and direct in vivo reprogramming (Modified from Yamashita et al. [28]). (a) Overexpression of Oct3/4, Sox2, Klf4, and c-Myc can…
Fig. 1.1 Overview of the proposed mechanisms of bone marrow-derived mononuclear cell (MNC)-based stroke therapies. Cells transplanted by intravenous (IV) or intra-arterial (IA) injection migrate toward the ischemic boundary zone…
© Springer Japan KK 2017Kiyohiro Houkin, Koji Abe and Satoshi Kuroda (eds.)Cell Therapy Against Cerebral Stroke10.1007/978-4-431-56059-3_2 2. Cell Therapy for Ischemic Stroke with Bone Marrow Stromal Cells Satoshi Kuroda1, 2 , Hideo Shichinohe2 and Kiyohiro Houkin2 (1) Department of Neurosurgery,…
Fig. 6.1 Schematic drawing of the transplantation route with its advantage and disadvantage 6.2.1 Intravenous Route One of the major advantages of using intravenous route for cell transplantation is its…
