Hemispherectomy: Indications, Procedures, and Outcome
Figure 84.1. Patient’s position for anatomical hemispherectomy. The head is then shaved and a “T”-shaped incision planned to allow access from the floor of the middle fossa to the midline…
Malformations of Cortical Development and Epilepsy
Table 26.2 Genetic Etiologies of Malformations of Cortical Development MALFORMATIONS OF CORTICAL DEVELOPMENT Accurate diagnosis of MCD relies primarily on recognition of the malformation on brain MRI, which, in turn,…
The Extratemporal Epilepsies
Figure 25.1. Dorsolateral FLE with seizures arising from the motor strip: a 21-year-old woman with simple partial seizures since a viral illness at age 9. Seizures began to cluster at…
Pharmacokinetics and Drug Interactions
aAfter administration of eslicarbazepine acetate. CYP, Cytochrome P450; UGT, UDP-glucuronosyltransferase; NAT, N-acetyltransferase; nk, not known. Figure 44.1. Relationship between pharmacokinetics and pharmacodynamics. PHARMACOKINETIC PARAMETERS Absorption Absorption refers to the passage…
Surgical Approach in Multilesional or Multilobar Epilepsies
Figure 85.1. Proposed algorithm for the evaluation of patients with multilobar and multilesional epilepsy. The algorithm departs from the findings in the brain MRI. The first element to consider is…
Rufinamide
Figure 62.1. Rufinamide. MW 238.2, (C10H8F2N4O). Rufinamide is nearly insoluble in water and slightly soluble in methanol and ethanol. This would make it difficult to prepare an intravenous formulation. Solubility…
