Figure 19.1 Standardized effect size (Cohen’s d) of vortioxetine (10 mg and 20 mg) on objective neuropsychological measures (McIntyre et al., 2014). Several lines of evidence indicate that subjective measures…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 18 Neuroscience of functional outcomes and treatment targets in major depressive disorder Lisanne M. Jenkins, Amy Peters, Rachel H. Jacobs, and Scott A. Langenecker Research is…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 14 White matter neurobiology and cognitive dysfunction in major depressive disorder Geoffrey Chern-Yee Tan and Kang Sim Introduction Major depressive disorder (MDD) is an affective disorder…
Figure 6.1 The impact of depression on cold cognitive function. Pooled, weighted Cohen’s d effect sizes reflecting the performance of currently depressed patients (black bars) and remitted depressed patients (gray…
Figure 13.1 A simplified diagram depicting the HPA axis and its feedback mechanism. Glucocorticoids, principally cortisol in humans, influence the expression of genes comprising approximately a fifth of the genome…
Figure 11.1 Neuropsychological model of depression. Adapted from Roiser et al. (2012), with permission. Cognitive deficits and the role of antidepressant treatment A review of antidepressant treatment effects on cognitive…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 10 Implications of cognitive impairments on functional outcomes in major depressive disorder Tracy L. Greer and Cassandra R. Hatt Introduction Impaired cognitive functioning is one of…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 9 Are cognitive deficits in major depressive disorder progressive? Marie Laure Cléry-Melin and Philip Gorwood Major depressive disorder (MDD) primarily involves mood disturbances, but its association…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> 8 The role of social cognition in major depressive disorder Bernhard T. Baune and Michael Weightman Introduction Correctly interpreting social information is a crucial part of…
Figure 7.1 SENSO framework showing biological, cognitive, neural, and behavioral responses following social rejection or threat of rejection. Legend: SAM: sympathetic adrenal medullary; vACC: ventral anterior cingulate; DMN: default mode…
