Neupsy Key

Fig. 24.1 Duchenne muscular dystrophy . (a) H&E shows dystrophic changes (asterisks indicate necrotic fibers, arrow indicates myofiber with abnormal internal architecture). (b) Immunostaining for dystrophin N terminus (DYS3) shows…

Fig. 22.1 H&E stained muscle biopsy section (a) shows striking endomysial fibrosis, abundant severely atrophic fibers and pyknotic nuclear clumps, and a few hypertrophic fibers. A split fiber is also…

Fig. 21.1 Muscle biopsy sections stained with H&E (a) shows markedly increased fiber size variation with a group of atrophic fibers (arrows), some hypertrophic fibers (#), and split fibers (∗)…

Fig. 19.1 Hydroxychloroquine myopathy. (a), Hematoxylin and eosin stain (HE) shows many scattered severely atrophic fibers , which are basophilic and contain sarcoplasmic vacuoles (arrows). Gomori trichrome stain (GT) shows…

Fig. 20.1 Calciphylaxis. (a), A picture of the patient’s back shows a large area of skin eschar (arrows). (b), Muscle biopsy with HE stain shows calcification of media tunica and…

Fig. 18.1 Hematoxylin and eosin stain (HE) shows a rare atrophic fiber (arrow) Final Diagnosis Mild Toxic Myopathy Induced by Statin Use Patient Follow-up The diagnosis of a mild toxic…

Fig. 16.1 HE stain shows increased internalized nuclei, a few necrotic fibers and myophagocytosis (a, arrows), and several fibers containing blue-rimmed sarcoplasmic vacuoles (b, arrows). Acid phosphatase stain shows a…

Fig. 14.1 Lipid storage myopathy. (a), HE stain shows many fibers containing multiple small sarcoplasmic vacuoles . Gomori trichrome stain (GT) shows these vacuoles are not red rimmed; a few…

Fig. 11.1 Quadriceps muscle biopsy shows mild chronic active myopathy . (a), Chronic features include marked fiber size variation, split fibers (black arrows) and frequent internalized nuclei (white arrows). (b),…