Fig. 27.1 Muscle biopsy findings of the left quadriceps. (a) H&E showing excessive variation of fiber diameters and mild increase in endomysial connective tissue. ATPase histochemistry (not shown) demonstrates that…
Fig. 26.1 Muscle biopsy findings of the right quadriceps muscle. (a) H&E showing excessive variation in fiber diameter, and increased numbers of fibers with centrally placed nuclei. (b) NADH-TR histochemistry…
Fig. 25.1 Muscle pathology in merosin deficiency. (a) H&E stained cryostat section shows an end stage muscle with few remaining fibers. Immunostaining shows intact alpha-dystroglycan (b) and dystrophin (c, DYS2…
Fig. 24.1 Duchenne muscular dystrophy . (a) H&E shows dystrophic changes (asterisks indicate necrotic fibers, arrow indicates myofiber with abnormal internal architecture). (b) Immunostaining for dystrophin N terminus (DYS3) shows…
Fig. 22.1 H&E stained muscle biopsy section (a) shows striking endomysial fibrosis, abundant severely atrophic fibers and pyknotic nuclear clumps, and a few hypertrophic fibers. A split fiber is also…
Fig. 21.1 Muscle biopsy sections stained with H&E (a) shows markedly increased fiber size variation with a group of atrophic fibers (arrows), some hypertrophic fibers (#), and split fibers (∗)…
Fig. 19.1 Hydroxychloroquine myopathy. (a), Hematoxylin and eosin stain (HE) shows many scattered severely atrophic fibers , which are basophilic and contain sarcoplasmic vacuoles (arrows). Gomori trichrome stain (GT) shows…
Fig. 20.1 Calciphylaxis. (a), A picture of the patient’s back shows a large area of skin eschar (arrows). (b), Muscle biopsy with HE stain shows calcification of media tunica and…
Fig. 18.1 Hematoxylin and eosin stain (HE) shows a rare atrophic fiber (arrow) Final Diagnosis Mild Toxic Myopathy Induced by Statin Use Patient Follow-up The diagnosis of a mild toxic…
Fig. 16.1 HE stain shows increased internalized nuclei, a few necrotic fibers and myophagocytosis (a, arrows), and several fibers containing blue-rimmed sarcoplasmic vacuoles (b, arrows). Acid phosphatase stain shows a…
