Abstract The current medical reform environment has signified a new era for health care delivery, physician accountability, and care optimization. In this context, outcomes data become a vital component in…
Abstract With the current trends in the healthcare environment, it has become essential to develop means with which to improve quality, patient satisfaction, and efficiency while reducing costs. These mounting…
Abstract Quality improvement and clinical research differ significantly, even though either may result in publication in medical literature. In the former, a single aspect of clinical practice is studied, a…
Abstract This chapter introduces the reader to the role organized neurosurgery has played in the past 10–15 years in its efforts to advance patient safety in neurosurgical practice. We discuss…
Abstract Recent years have seen a steady increase in the attention paid to quality and safety with regard to hospitalized patients. The topic has transitioned from being a lofty ideal…
Abstract Currently, 17 transcription factors are known to form the Krüppel-like factor (KLF) family. All transcription factors of the KLF family resemble the members of the specificity protein (Sp) family;…
Abstract The small non-coding RNAs are called microRNAs or miRNAs that play key roles in mRNA silencing as well as in post-transcriptional regulation of gene expression in eukaryotic cells. The…
Abstract Neuroblastoma is the most common malignancy in infancy and the most common extracranial solid tumor in the pediatric age group. There is only approximately 30%–40% long-term survival rates among…
Abstract This chapter introduces the molecular targeted therapies and immunotherapies currently in use to treat neuroblastoma, which is the most common extracranial solid tumor in children. It presents a clinical…
Abstract Antiangiogenic strategies are currently in use for the treatment of cancer, and the inhibition of angiogenesis could represent a powerful adjunct to traditional therapy of malignant tumors. Over the…
