Anatomy of the Nervous System
Abstract This chapter briefly reviews the organization and gross structures of the central nervous system and its primary motor and sensory pathways. Keywords Brain, Nervous system, Pyramidal motor system, Sensory…
Psychological Issues and Evaluation for Patients Undergoing Implantable Technology
Abstract Psychological assessment of patients undergoing neuromodulation for chronic disorders has generally not kept pace with the advancements in the technology and its broadening application. This chapter describes how general…
Perspectives on the History of Neuromodulation-Relevant Societies
Abstract This chapter turns to the history of the beginnings of the societies that are important to the founding of a medically relevant paradigm, in this instance, neuromodulation. The International…
Challenges in Clinical Design of Immunotherapy Trials for Malignant Glioma
Glioblastoma multiforme (GBM) is the most common and lethal primary malignant brain tumor. The traditional treatments for GBM, including surgery, radiation, and chemotherapy, only modestly improve patient survival. Therefore, immunotherapy…
Monitoring Immune Responses After Glioma Vaccine Immunotherapy
Immunotherapy provides the ideal candidate of therapeutic attack against malignant gliomas because it allows for targeting of cancer cells without the potential for nonspecific toxicity. This is important when glial…
Immunotherapy Combined with Chemotherapy in the Treatment of Tumors
This article provides a broad overview of the data, including laboratory and clinical studies, currently available on the combination of immunotherapy and chemotherapy for treating cancer. The various forms of…
Distinguishing Glioma Recurrence from Treatment Effect After Radiochemotherapy and Immunotherapy
Recent advancements have made radiation and chemotherapy the standard of care for newly diagnosed glioblastomas. The use of these therapies has resulted in an increased diagnosis of pseudoprogression and radiation-induced…
Glioma Stem Cell Research for the Development of Immunotherapy
Glioma, especially high-grade glioblastoma multiforme (GBM), is the most common and aggressive type of brain tumor, accounting for about half of all the primary brain tumors. Despite continued advances in…
Dendritic Cell Vaccines for Brain Tumors
Over the past decade, dendritic cell–based immunotherapy for central nervous system tumors has progressed from preclinical rodent models and safety assessments to phase I/II clinical trials in over 200 patients,…
Virally Mediated Immunotherapy for Brain Tumors
Brain tumors are a leading cause of mortality and morbidity in the United States. Malignant brain tumors occur in approximately 80,000 adults. Furthermore, the average 5-year survival rate for malignant…
