Intense Low-Density Lipoprotein Cholesterol Reduction for Stroke Prevention High-Dose Atorvastatin after Stroke or Transient Ischemic Attack SPARCL Investigators. NEJM. 2006;355:549-559 BACKGROUND Prior to SPARCL, there was no compelling evidence to…
Novel Oral Anticoagulants for Stroke Prevention in Nonvalvular Atrial Fibrillation Dabigatran versus Warfarin in Patients with Atrial Fibrillation Connolly SJ, Ezekowitz MD, Yusuf S, et al; RE-LY Steering Committee and…
Warfarin for Atrial Fibrillation Stroke Prevention in Atrial Fibrillation Study: Final Results Stroke Prevention in Atrial Fibrillation Investigators. Circulation. 1991;84:527-539 BACKGROUND Atrial fibrillation (AF) increases the risk of ischemic stroke…
Harm from Stenting of Symptomatic Intracranial Arterial Stenoses Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenoses Chimowitz MI, Lynn MJ, Derdeyn CP, et al; SAMMPRIS Trial Investigators. NEJM. 2011;365:993-1003…
Mechanical Thrombectomy for Large Vessel Occlusion A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke Berkhemer OA, Fransen PSS, Beumer D, et al. NEJM. 2015;372:11-20 BACKGROUND Large artery occlusions…
Aspirin for Secondary Stroke Prevention Collaborative Overview of Randomised Trials of Antiplatelet Therapy—I: Prevention of Death, Myocardial Infarction, and Stroke by Prolonged Antiplatelet Therapy in Various Categories of Patients Antiplatelet…
Intravenous tPA for Acute Ischemic Stroke Tissue Plasminogen Activator for Acute Ischemic Stroke The National Institute of Neurological Disorders and Stroke rt-PA Study Group. NEJM. 1995;333(24):1581-1587 BACKGROUND At the time…
In this chapter we present additional disorders that can cause memory loss and other cognitive impairment. Although some of these disorders are common, because none are causes of dementia per…
Quick Start Cholinesterase Inhibitors Mechanism of action and cognitive benefit • Cholinesterase inhibitors increase the concentration of acetylcholine at the synapse and improve memory, attention, mood, and behavior. • Cholinesterase…
Because of the rapid aging of the population and the accompanying increase in the prevalence of Alzheimer’s disease, there is enormous interest from both the federal government and private industry…
