Antiepileptic Drug Development and Experimental Models Jacqueline A. French In 1962, the Kefauver-Harris amendments to the federal Food, Drug, and Cosmetic Act ushered in the modern age of drug testing…
Other Nonepileptic Paroxysmal Disorders John M. Pellock A number of conditions cause intermittent and recurring symptoms that suggest epilepsy. Although seizures must be considered in the differential diagnosis, the clinical…
Status Epilepticus James J. Riviello Jr. Status epilepticus (SE) is a life-threatening medical emergency that requires prompt recognition and immediate treatment. SE is not a disease in itself but rather…
Psychogenic Nonepileptic Seizures Selim R. Benbadis OVERVIEW Psychogenic nonepileptic seizures (PNES) are routinely seen at epilepsy centers, where they represent 15% to 30% of patients referred for refractory seizures (1,2)….
Epilepsy in Patients with Multiple Handicaps John M. Pellock Disabilities associated with the varying etiologies of epilepsy or with the disease itself often lead to multiple handicaps that complicate the…
Epilepsy in the Elderly Ilo E. Leppik Angela K. Birnbaum The elderly (persons 65 years of age and older) are the most rapidly growing segment of the population, and onset…
Seizures Associated with Nonneurologic Medical Conditions Stephan Eisenschenk Robin L. Gilmore Seizures frequently arise during the course of medical illnesses that do not primarily affect the central nervous system (CNS)….
Epilepsy in the Setting of Inherited Metabolic and Mitochondrial Disorders Linda D. Leary Douglas R. Nordli Jr. Darryl C. De Vivo There are more than 11,000 well-recognized and well-characterized inherited…
Epilepsy in the Setting of Neurocutaneous Syndromes Prakash Kotagal Deepak K. Lachhwani The neurocutaneous syndromes are a group of unrelated disorders characterized by congenital dysplastic abnormalities involving the skin and…
Epilepsy in the Setting of Cerebrovascular Disease Bernd Pohlmann-Eden Martin Del Campo Neil R. Friedman Deepak K. Lachhwani Cerebrovascular disease (CVD) is a leading cause of neurologic morbidity across all…
