Chapter 12 – fMRI Neurofeedback as Treatment for Depression
Abstract We urgently need new therapeutic strategies for depression (1). Depression is one of the top three causes of disability in the global disease burden statistic, affecting up to 15%…
Chapter 10 – Neuroimaging Brain Inflammation in Mood Disorders
Abstract Neuroimaging with positron emission tomography is increasingly developing radioligands that emulate targets traditionally within the domain of postmortem studies. Consequently, markers indicative of neuroinflammatory processes are advancing and enabling…
Chapter 11 – Imaging Genetic and Epigenetic Markers in Mood Disorders
Abstract Genetics explain 60–85% and 31–50% of the risk to develop, respectively, bipolar disorder (BD) (1, 2) and major depressive disorder (MDD) (3, 4). Thus, hereditability has emerged as a…
Chapter 9 – Imaging Glutamatergic and GABAergic Abnormalities in Mood Disorders
Abstract Glutamate (Glu) and gamma-aminobutyric acid (GABA) are the main brain excitatory and inhibitory neurotransmitters. These neurotransmitters are involved in neural migration, differentiation, and synaptic plasticity (1–6). There are accumulating…
Chapter 8 – Magnetic Resonance Spectroscopy Investigations of Bioenergy and Mitochondrial Function in Mood Disorders
Abstract Major depressive disorder (MDD) and bipolar disorder (BD) are likely to be etiologically diverse, resulting from the contributions of multiple pathophysiologic processes present in affected individuals to varying degrees….
Chapter 7 – Functional Connectome in Bipolar Disorder
Abstract Bipolar disorder (BD) is a major psychiatric illness which is thought to have strong biological underpinnings. A biological basis for BD is exemplified by a strong heritability of the…
Chapter 6 – Resting-State Functional Connectivity in Unipolar Depression
Abstract Unipolar depression, also known as unipolar or major depressive disorder (MDD), is a globally prevalent psychiatric disorder characterized by persistent sadness and a loss of interest in normally enjoyable…
Chapter 5 – Brain Imaging of Reward Dysfunction in Unipolar and Bipolar Disorders
Abstract In recent years, there has been tremendous support for working toward the RDoC goals of identifying the neurobiological mechanisms that cut across or are common to multiple psychiatric disorders….
Chapter 4 – Neuroimaging Biomarkers in Pediatric Mood Disorders
Abstract Mood disorders, including bipolar disorder (BD) and major depressive disorder (MDD), are serious and often-recurring psychiatric conditions that commonly first manifest during childhood or adolescence (1, 2). Youth with…
Chapter 3 – Neuroanatomical Findings in Bipolar Disorder
Abstract Over the past three decades, numerous cross-sectional neuroimaging studies have reported neuroanatomical abnormalities in patients with bipolar disorder compared with healthy volunteers. These studies have highlighted those anatomical regions…
