Genomics of Anxiety Disorders
Anxiety disorders are the most prevalent psychiatric conditions in the general population. Despite the early observation of family aggregation of anxiety disorders with a heritability of 30% to 50%, their…
Genomics of Attention Deficit Hyperactivity Disorder
This report provides an update on current knowledge and applications of genomic research in attention deficit hyperactivity disorder (ADHD). The history, principles, and underlying assumptions for genetic studies on psychiatric…
Mainstreaming Diagnostic Genetic Testing and Precision Medicine for Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental psychiatric condition that shares significant clinical and genetic overlap with intellectualdisability (ID) and other neurodevelopmental disorders. Genetic testingin ASD lags far behind that…
Genomics of Bipolar Disorder
Bipolar disorder (BD) affects approximately 2% of the global population, characterized by alternating episodes of mania or hypomania, and depression. It comprises two main types: bipolar I disorder, marked by…
Recent Advances in Schizophrenia Genomics and Emerging Clinical Implications
The conceptualization of schizophrenia has evolved from Emil Kraepelin’s identification of “dementia praecox” as a distinct illness characterized by cognitive and functional deficits to the modern understanding of its complex…
Genetics of Anorexia Nervosa
Anorexia nervosa (AN) is a debilitating and often refractory eating disorder that is unique among psychiatric disorders insofar as nutrition is key to recovery. Treatment options and efficacy are limited…
Tourette Syndrome and Chronic Tic Disorders
Tourette syndrome (TS) and chronic tic disorder (CTD) are characterized by persistent verbal and motor tics of varying severity. We describe modern genetic studies of TS/CTD focused on common and…
Psychiatric Pharmacogenomic Testing
Pharmacogenomic (PGx) testing is an evidence-based strategy to optimize the selection and dosing of certain psychotropic medications. An individual’s genetics play a role in medication response through pharmacokinetic and pharmacodynamic…
Ethical Considerations in Psychiatric Genomics
The ethics of psychiatric genetics and genomics is an emerging field, distinct from general genetics. Key ethical concerns include the implications for personhood and identity, the dual perception of psychiatric…
Diversifying Psychiatric Genomics
The underrepresentation of non-European researchers, participants, and datasets in psychiatric genetics hinders the understanding of mental health conditions and perpetuates health inequities. Ancestral diversity in research is crucial for advancing…
