Inherited Neurodegenerative Disorders: Introduction Print Section Listen Understanding the inherited neurodegenerative diseases of childhood has evolved dramatically in the past 40 years. Fundamental discoveries in biochemistry uncovered the metabolic basis…
Genetic Testing For Neurological Disorders: Introduction Print Section Listen Many of the neurological disorders discussed in this book have a genetic etiology that can be diagnosed and/or confirmed by chromosomal…
Tuberous Sclerosis Print Section Listen Definitions and Epidemiology Tuberous sclerosis is a genetic disease occurring in approximately 1 in 10,000 people. It is inherited in an autosomal dominant pattern isolated…
Meningitis Print Section Listen Definitions and Epidemiology Meningitis is defined as an inflammation of the leptomeninges by any cause. Bacteria cause meningitis by invading and replicating in the subarachnoid space…
Toxic and Metabolic Encephalopathies: Introduction Print Section Listen Metabolic disorders and disorders caused by exposure to a toxic agent portend a good prognosis, leading most of the time to a…
Multiple Sclerosis White Matter: Introduction Print Section Listen Demyelination is a process that results in either partial or complete loss of the myelin sheath following a period of normal myelin…
Muscle Diseases Print Section Listen The myopathies are neuromuscular disorders in which the primary symptom is muscle weakness due to dysfunction of muscle fiber. In pediatric patients, myopathies can be…
Definitions and Epidemiology Print Section Listen Traumatic brain injury (TBI) is a leading cause of death and disability among children and young adults.1,2 Unintentional injuries (ie, car accidents and falls)…
General Approach to Peripheral Neuropathies Print Section Listen History A thorough history is vital in the evaluation of neuromuscular diseases. The presentation of a peripheral neuropathy in the pediatric population…
