Perspective on How to Build a Neuromodulation Practice ∗
Abstract Building a neuromodulation practice is a challenge in this world of cost cutting and cost saving. But for physicians, dedicated to bringing access of this important therapy to their…
NEUROLOGY
Neuromodulation : Regulatory Considerations
Abstract Researchers and companies developing new concepts in neuromodulation will, at some point, find themselves navigating the US Food and Drug Administration (FDA) regulatory programs, whether during the conduct of…
Novel Methods of Transcranial Stimulation : Electrosonic Stimulation
Abstract The use of electricity for therapeutic purposes was first used almost 2000 years ago. Today, based on advancements in both electrophysiology and electromagnetic theory, numerous electromagnetic-based techniques and technologies…
Optimization of Noninvasive Brain Stimulation Clinical Trials
Abstract Clinical trials in noninvasive brain stimulation (NIBS), such as transcranial electrical stimulation and transcranial magnetic stimulation, have been conducted over the past 15 years to evaluate their potential therapeutic…
Insulin Resistance, Glucose Metabolism, Inflammation, and the Role of Neuromodulation as a Therapy for Type-2 Diabetes
Abstract Muscle and fat cells, unlike nerve and immune cells, require insulin for the efficient uptake of circulating glucose. Prolonged inflammation and the expression of key cytokines have the effect…
The Role of Vagus Nerve Stimulation in the Treatment of Central and Peripheral Pain Disorders and Related Comorbid Somatoform Conditions
Abstract While the evidence for many applications of vagus nerve stimulation (VNS) is preliminary, new noninvasive VNS devices have recently been developed and represent significant advancements in VNS therapy. A…
Bioelectronic Therapy for the Treatment of Rheumatoid Arthritis and Inflammatory Bowel Disease
Abstract Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) cause significant morbidity and mortality despite significant advances in treatment. A large body of preclinical work has shown that vagus nerve…
Sacral Nerve Root Stimulation for Bladder Pain Syndrome/Interstitial Cystitis
Abstract Bladder pain syndrome/interstitial cystitis (BPS/IC) is a severely debilitating, chronic disorder characterized by pain perceived to arise from the bladder, exacerbated by bladder filling, and associated with urinary urgency…
Restoration of Cough via Functional Electrical Stimulation
Abstract While restoration of inspiratory muscle function to restore breathing in ventilator-dependent spinal cord injured (SCI) subjects is an important clinical modality, restoration of expiratory muscle function may be even…
Activation of the Inflammatory Reflex in Rheumatoid Arthritis and Inflammatory Bowel Disease; Preclinical Evidence
Abstract The “inflammatory reflex” is an important neural-immune mechanism that can be activated by electrical vagus nerve stimulation (VNS) to drive pleiotropic antiinflammatory effects in the periphery. It has therefore…
