Fig. 30.1 a A 57-year-old man with acute lymphoblastic leukemia presented with right-sided Bell’s palsy, a left-sided vocal cord paralysis and an abducens nerve palsy on the right. T1-weighted MRI brain…

Fig. 33.1 Incidence of pediatric cancers. Age-adjusted and age-specific SEER cancer incidence rates, 2008–2012, all races, male and female, ages 0–19. (Created from data in Howlader N, Noone AM, Krapcho M,…

Fig. 26.1 CNS complications of choriocarcinoma. Representative images of an aneurysmal hemorrhage from choriocarcinoma. a, b CT head shows an intraparenchymal hemorrhage in the right temporoparietal lobe with mass effect. Axial…

Time point Complication Stem cell harvest Intracranial hypotension due to entry into subarachnoid space during bone marrow aspiration Worsening neurologic manifestations of underlying autoimmune syndrome, possibly related to G-CSF Conditioning…

Hematologic disorder Most common monoclonal protein type Neuropathy phenotype Autonomic involvement Helpful laboratory markers Monoclonal gammopathy of undetermined significance IgM kappa Length-dependent, sensory predominant, demyelinating with prolonged distal latencies –…

Fig. 28.1 Histological analysis of perineural invasion of HNSCC. Perineural (a) and intraneural invasions (b) by squamous cell carcinoma of the head and neck (H&E staining). White dotted lines indicate the…

Agent Therapeutic target(s)/mechanism of action Use(s) in cancer treatment Common neurologic toxicities (≥10% of patients) Rare neurologic toxicities (<10%) Monoclonal antibodies Bevacizumab VEGF-A Metastatic colorectal cancer, nonsquamous NSCLC, platinum-resistant ovarian…

Fig. 31.1 MRI lumbar spine T1 post-contrast sagittal image showing leptomeningeal enhancement of the cauda equina and lumbosacral nerve roots in a 74-year-old man with a transformed follicular lymphoma, presenting with…

Fig. 11.1 Obstructive hydrocephalus due to an intraventricular mass. Contrast-enhanced sagittal (a) and axial (b) T1-weighted images showing an enhancing lesion (arrows) occluding the outflow of the fourth ventricle. The patient…

Type of cancer % Breast cancer Lung carcinoma Melanoma Gastrointestinal tract cancer Adenocarcinoma of unknown primary 12–34 10–26 17–25 4–14 1–7 Data from References [1–6] Used from Le Rhun E,…