Fig. 1 Stages of the cDNA microarray technology Why use cDNA rather than RNA purified directly? First, the population of RNA after purification is a mix of different kinds of…
Type of ventilation (references) Strain Behavioral effect Three different types of IVC racks [17] BALB/c Avoid high intra cage ventilation but preference counteracted by nesting material Prefer larger cages with…
Fig. 1 Common molecular pathways in invertebrates with respect to vertebrates could help in understanding some of the molecular mechanisms involved in autism spectrum disorders. At present more than 500…
Fig. 1 Gene ontology (cellular components) of the 66 ASD-associated genes. The insert details the neuronal components Fig. 2 Gene ontology (molecular processes) of the 66 ASD-associated genes Fig. 3…
Neurodevelopmental deficits typical of autism in humans Triad grouping Nonhuman primates Behavioral deficits resulting from trauma, social isolation, and poor living conditions Behavioral deficits in captivity Behavioral deficits in wild…
Fig. 1 Schematic representation of the TSC1 and TSC2 proteins, showing phosphorylation sites and important structural and functional features [15]. Numbers are according to the human amino acid sequences. 3…
Fig. 1 Induced pluripotent stem cells strategy to orient cell development towards differentiated neurons Taking fibroblasts in patients with a genetic disease, transforming the adult cells into iPSCs and reprogramming…
Fig. 1 The figure summarizes neurobiological processes that have been found to be abnormal in mouse models of tuberous sclerosis and that could contribute to the neuropsychiatric manifestations associated with…
Fig. 1 Schematic representation of the Mecp2 gene and localization of the modifications made to engineer Mecp2-deficient mouse models. See text for details Hundreds of MECP2 mutations are known in…
Animal models 5-HT-related abnormalities Region References Developmental hyperserotonemia model (DHS) Increase Whole (nonspecific 5-HT receptors agonist) [37, 38, 113] VPA treatment for embryo Decrease/Increase 5-HT Abnormal migration of 5-HT neurons…
