Imaging Disease Progression
Fig. 6.1 Simulated data demonstrating how cross-sectional data (a) may not reveal an association (in this case positive) with time that is clearly seen with longitudinal data (b). Measurement values…
NEUROLOGY
Current Treatments for Progressive Multiple Sclerosis: Disease-Modifying Therapies
Characteristics of the placebo cohorts at baseline in the seven SPMS phase III RCTs Baseline variable (reference) European-SPMS NA- SPMS SPECTRIMS IMPACT Nordic-SPMS MIMS ESIMS IFNB-1b sc [18] IFNB-1b sc…
Epidemiology of Progressive Multiple Sclerosis
Study N Time to EDSS endpoint 3 4 6 7 8 10 Cottrell [5] 216 4 5 8 15 18 34 Tremlett et al. [18] 352 13.3 Andersson et al….
Future Therapies for Progressive Multiple Sclerosis
Fig. 10.1 The first electron microscopic images showing what the authors termed “abortive remyelination” – spontaneous myelin repair – at the edge of a multiple sclerosis plaque (Reproduced with permission…
Mechanisms of Disease Progression
Fig. 5.1 Potential mechanisms of axonal injury in progressive MS 5.4.1 Inflammation Inflammatory mediators have long been implicated in the pathophysiology of MS [35]. A variety of cellular and soluble…
What Is Disease Progression?
Extrinsic structural lesions causing spinal cord compromise Degenerative cervical spine disease/cervical spondylosis Extrinsic tumor such as meningioma (Epidural abscess) Intrinsic structural lesions causing spinal cord compromise Syringomyelia Intrinsic tumor of…
General Introduction
Fig. 1.1 Disease course patterns in MS: (a) Relapsing and Remitting MS (RRMS): clearly defined acute attacks with recovery. (b) Primary Progressive MS (PPMS): progression of disability from onset without…
Clinical Use of OCT and MSON Mimics
Differential diagnosis Clinical features MSON Mostly good recovery within 2 months ION Isolated ON RION Isolated ON with spontaneous relapses CRION Relapses on steroid withdrawal, poor recovery NMO-ON Relapses, poor…
Optical Coherence Tomography (OCT)
Fig. 3.1 The setup should allow for good OCT examination conditions. Patients may require wheelchair access and additional help during the assessment for which there needs to be sufficient space….
OCT in Relapsing–Remitting Multiple Sclerosis (RRMS)
Fig. 8.1 Panel (a) represents a fundus photograph from a healthy control. Panel (b) is a 3D macular volume cube generated by Cirrus HD-OCT from the macular region denoted by…
