Figure 59.1. 2-(2-oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile hydrate, M.W. 349.38 (perampanel). PERAMPANEL PHARMACOLOGY Glutamate is the major excitatory neurotransmitter in the CNS. Fast glutaminergic transmission is mediated predominantly by NMDA and AMPA receptors…
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Figure 58.1. The chemical structure of LEV. MECHANISM OF ACTION Prior to undergoing standardized AED testing by the National Institutes of Health, LEV was found to have antiepileptic properties. In…
The following overview of nonepileptic paroxysmal disorders is organized by age, type, and time of occurrence. Psychogenic nonepileptic seizures are discussed in Chapter 40. INFANCY Sleep During infancy, at least…
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Figure 87.1. Preliminary cellular model for HH epileptogenesis based upon laboratory findings derived from surgically resected HH tissue [references (21–27); reviewed in (22)]. A photomicrograph of HH tissue is shown…
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TYPICAL ABSENCE SEIZURES Clinical Features Typical absence seizures last an average of 10 seconds, are usually provoked by hyperventilation, and postictal confusion is either absent or very brief (7,8). The…
