NEUROLOGY

The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance

Mar 17, 2017 by in NEUROLOGY Comments Off on The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance

Fig. 24.1 General schematic of cellular GSH biosynthesis, utilization, export, and salvage. Glutathione (GSH) biosynthesis requires two ATP-dependent reactions: the glutamate cysteine ligase (GCL)-mediated formation of γ-glutamylcysteine (γGC) from glutamate…

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