Fig. 3.1 Relationship between CSF–serum ratio of blood (white circles) and brain-derived (black circles) compounds and their hydrodynamic radius under “steady-state” conditions (Modified according to Felgenhauer (1995)). Alb albumin, α2-M…
and Cheng-Ying Ho2 (1) Pathology, Johns Hopkins University, Baltimore, Maryland, USA (2) Pathology, Children’s National Medical Center, Washington, D.C., District of Columbia, USA General Considerations Routine biomarkers in use in…
and Cheng-Ying Ho2 (1) Pathology, Johns Hopkins University, Baltimore, Maryland, USA (2) Pathology, Children’s National Medical Center, Washington, D.C., District of Columbia, USA Diffuse Gliomas in Adults Clinical and Pathologic…
and Cheng-Ying Ho2 (1) Pathology, Johns Hopkins University, Baltimore, Maryland, USA (2) Pathology, Children’s National Medical Center, Washington, D.C., District of Columbia, USA Current Biomarkers in Neoplastic Neuropathology Enormous advances…
and Cheng-Ying Ho2 (1) Pathology, Johns Hopkins University, Baltimore, Maryland, USA (2) Pathology, Children’s National Medical Center, Washington, D.C., District of Columbia, USA General Considerations One of the main advantages…
and Cheng-Ying Ho2 (1) Pathology, Johns Hopkins University, Baltimore, Maryland, USA (2) Pathology, Children’s National Medical Center, Washington, D.C., District of Columbia, USA General Considerations Biobanks are biorepositories of human…
Fig. 1 Illustration of differential gene expression profiling in Huntington’s disease (HD) systems. In this approach, cumulative cellular events relating to the disease process are described by “molecular snapshots” that…
Fig. 1 ChIP-seq workflow. Major steps in experimental procedure include cell collection and cross-linking, sonication of chromatin to achieve desired fragment length, antibody pulldown, library preparation, and sequencing 2 Materials…
Fig. 1 A scheme of integration of biotechnologies and applications for development of personalized medicine The role of neurogenomics in the development of personalized neurology is shown schematically in Fig….
Year Discovery/landmark/reference Pregenomic era 1871 Discovery of nucleic acids 1889 Hugo de Vries postulated “pangene” to be a living, self-replicating unit of heredity. His postulation was adapted from Darwin’s “pangenesis”…
