Carbamazepine and Oxcarbazepine
Carbamazepine and Oxcarbazepine Carlos A. M. Guerreiro Marilisa M. Guerreiro Carbamazepine (CBZ) is one of the most often prescribed drugs worldwide for the treatment of neurologic disorders. It has been…
NEUROLOGY
Pharmacogenetics of Antiepileptic Medications
Pharmacogenetics of Antiepileptic Medications Tracy A. Glauser Diego A. Morita Marked interindividual variation in efficacy and adverse effects, a characteristic of antiepileptic drug (AED) therapy, represents the result of a…
Monitoring for Adverse Effects of Antiepileptic Drugs
Monitoring for Adverse Effects of Antiepileptic Drugs L. James Willmore Andrew Pickens IV John M. Pellock Treatment of patients with epilepsy aims for complete seizure control without intolerable drug side…
Treatment of Epilepsy in the Setting of Renal and Liver Disease
Treatment of Epilepsy in the Setting of Renal and Liver Disease Jane G. Boggs Elizabeth Waterhouse Robert J. DeLorenzo Management of seizures in the presence of renal and liver disease…
Treatment of Epilepsy During Pregnancy
Treatment of Epilepsy During Pregnancy Nancy Foldvary-Schaefer Epilepsy affects nearly 1% of the population, including almost 1 million women of childbearing potential (1). The management of epilepsy during pregnancy can…
Hormones, Catamenial Epilepsy, and Reproductive and Bone Health in Epilepsy
Hormones, Catamenial Epilepsy, and Reproductive and Bone Health in Epilepsy Martha J. Morrell Steroid hormones alter the excitability of neurons of the cerebral cortex and thereby alter the seizure threshold….
Initiation and Discontinuation of Antiepileptic Drugs
Initiation and Discontinuation of Antiepileptic Drugs Varda Gross Tsur Christine O’Dell Shlomo Shinnar Supported in part by grant 1 R01 NS26151 (S. Shinnar) from the National Institute of Neurological Disorders…
Pharmacokinetics of Antiepileptic Drugs in Infants and Children
Pharmacokinetics of Antiepileptic Drugs in Infants and Children Gail D. Anderson Jong M. Rho Over the past 20 years, the greater susceptibility to seizures of the immature brain, compared with…
Pharmacokinetics and Pharmacodynamics of Antiepileptic Drugs
Pharmacokinetics and Pharmacodynamics of Antiepileptic Drugs Blaise F. D. Bourgeois The principles of pharmacokinetics and pharmacodynamics are heavily rooted in mathematics and may, at first, appear far removed from clinical…
Antiepileptic Drug Development and Experimental Models
Antiepileptic Drug Development and Experimental Models Jacqueline A. French In 1962, the Kefauver-Harris amendments to the federal Food, Drug, and Cosmetic Act ushered in the modern age of drug testing…
